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• W1990004551 abstract "Venous malformations (VM) are well seen on T2 weighted MRI sequences, but 2D measurements could be less reproducible because of VM irregular shapes. Also, perfusion analysis is subjective. We hypothesize that software allowing 3D volumetric evaluation and perfusion analysis would be more accurate to evaluate VM response to sclerotherapy. Out of 44 patients who underwent baseline MRI, 19 were treated and had MRI follow-up. All patients had two 2D orthogonal STIR acquisitions followed by a perfusion study (T1) at 1, 2, 5 and 10min after contrast injection (Multihance 0.1mmole/kg) using 3D VIBE acquisitions. Blinded manual measurements of VM maximal diameter were undertaken by two investigators in three perpendicular axis on STIR acquisitions. From this, the mean diameter was calculated. With a dedicated software (Object Research System), the same investigators performed a 3D volumetric reconstruction of VM using orthogonal STIR acquisitions. This model was fused with VIBE perfusion sequences and percentage of perfusion was analysed. Inter-observers reproducibility was analyzed with intraclass correlation coefficient. Perfusion percentage at baseline was compared using student t-test between VM with a volume diminution of at least 50% and those without a significant reduction. Finally, VM variation after sclerotherapy was evaluated with manual and volumetric measurements. For baseline MRI, inter-observer correlations were estimated at 0.99 for volumetric measurements and 0.98 for manual measurements. Improved correlation was found for the estimation of VM variation after sclerotherapy using volumetric measurements (ICC=0.85) compared to manual measurements (ICC=0.45). No difference in perfusion percentage was found for patients having clinical successes or failures(p=0.2). Volumetric assessment of VM at baseline is as reproducible as manual measurement of mean diameters. However, volumetric assessment of VM is more reproducible than 2D measurements to evaluate clinical response following sclerotherapy. Perfusion analysis of VM have no correlation with better clinical successes. Still, visualization of perfused areas could be helpful to guide sclerotherapy sessions." @default.
• W1990004551 created "2016-06-24" @default.
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• W1990004551 date "2009-02-01" @default.
• W1990004551 modified "2023-09-26" @default.
• W1990004551 title "Abstract No. 141: Clinical Validation of a Semi-Automated Software for Volumetric and Perfusion Analysis of Soft Tissue Venous Malformation on MRI Examination" @default.
• W1990004551 doi "https://doi.org/10.1016/j.jvir.2008.12.126" @default.
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