Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990005890> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W1990005890 endingPage "349" @default.
- W1990005890 startingPage "342" @default.
- W1990005890 abstract "Fasciculins are peptides isolated from mamba (Dendroaspis) venoms which exert their toxic action by inhibiting acetylcholinesterase (AChE). They contain a characteristic triple stranded antiparallel beta-sheet formed by residues 22-27, 34-39 and 48-53. A chimeric peptide named Fas-C, encompassing most of these sequences was synthesized using SPPS/Boc-chemistry and characterized chemically, structurally and functionally. Fas-C has two disulfide bridges, formed sequentially using dual cysteine protection. SDS-PAGE patterns, HPLC profiles and MS proved the peptide identity. Circular dichroism indicated the presence of 13.6% and 41.6% of beta-sheet and beta-turn, respectively, comparable to values observed in the native toxin. An inhibitory effect on eel AChE was displayed by the peptide (Ki71.6 +/- 18.3 microM), although not reaching the affinity level of the parent native toxin (Ki 0.3 nM). It is confirmed that the principal binding region of fasciculin to AChE resides within loop II." @default.
- W1990005890 created "2016-06-24" @default.
- W1990005890 creator A5010324645 @default.
- W1990005890 creator A5047708260 @default.
- W1990005890 creator A5052047675 @default.
- W1990005890 date "2004-05-24" @default.
- W1990005890 modified "2023-10-06" @default.
- W1990005890 title "Synthesis and characterization of a chimeric peptide derived from fasciculin that inhibits acetylcholinesterase" @default.
- W1990005890 doi "https://doi.org/10.1002/psc.554" @default.
- W1990005890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15214439" @default.
- W1990005890 hasPublicationYear "2004" @default.
- W1990005890 type Work @default.
- W1990005890 sameAs 1990005890 @default.
- W1990005890 citedByCount "4" @default.
- W1990005890 countsByYear W19900058902016 @default.
- W1990005890 countsByYear W19900058902017 @default.
- W1990005890 crossrefType "journal-article" @default.
- W1990005890 hasAuthorship W1990005890A5010324645 @default.
- W1990005890 hasAuthorship W1990005890A5047708260 @default.
- W1990005890 hasAuthorship W1990005890A5052047675 @default.
- W1990005890 hasConcept C115260700 @default.
- W1990005890 hasConcept C121332964 @default.
- W1990005890 hasConcept C133571119 @default.
- W1990005890 hasConcept C142089489 @default.
- W1990005890 hasConcept C181199279 @default.
- W1990005890 hasConcept C185592680 @default.
- W1990005890 hasConcept C2778816929 @default.
- W1990005890 hasConcept C2779201268 @default.
- W1990005890 hasConcept C2779281246 @default.
- W1990005890 hasConcept C2779448229 @default.
- W1990005890 hasConcept C55493867 @default.
- W1990005890 hasConcept C62520636 @default.
- W1990005890 hasConcept C71240020 @default.
- W1990005890 hasConceptScore W1990005890C115260700 @default.
- W1990005890 hasConceptScore W1990005890C121332964 @default.
- W1990005890 hasConceptScore W1990005890C133571119 @default.
- W1990005890 hasConceptScore W1990005890C142089489 @default.
- W1990005890 hasConceptScore W1990005890C181199279 @default.
- W1990005890 hasConceptScore W1990005890C185592680 @default.
- W1990005890 hasConceptScore W1990005890C2778816929 @default.
- W1990005890 hasConceptScore W1990005890C2779201268 @default.
- W1990005890 hasConceptScore W1990005890C2779281246 @default.
- W1990005890 hasConceptScore W1990005890C2779448229 @default.
- W1990005890 hasConceptScore W1990005890C55493867 @default.
- W1990005890 hasConceptScore W1990005890C62520636 @default.
- W1990005890 hasConceptScore W1990005890C71240020 @default.
- W1990005890 hasIssue "6" @default.
- W1990005890 hasLocation W19900058901 @default.
- W1990005890 hasLocation W19900058902 @default.
- W1990005890 hasOpenAccess W1990005890 @default.
- W1990005890 hasPrimaryLocation W19900058901 @default.
- W1990005890 hasRelatedWork W116961403 @default.
- W1990005890 hasRelatedWork W1990005890 @default.
- W1990005890 hasRelatedWork W1996060883 @default.
- W1990005890 hasRelatedWork W2009283113 @default.
- W1990005890 hasRelatedWork W2045401917 @default.
- W1990005890 hasRelatedWork W2051541255 @default.
- W1990005890 hasRelatedWork W2074313989 @default.
- W1990005890 hasRelatedWork W2405820425 @default.
- W1990005890 hasRelatedWork W4282918324 @default.
- W1990005890 hasRelatedWork W4302307631 @default.
- W1990005890 hasVolume "10" @default.
- W1990005890 isParatext "false" @default.
- W1990005890 isRetracted "false" @default.
- W1990005890 magId "1990005890" @default.
- W1990005890 workType "article" @default.