FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990042464> ?p ?o ?g. }

• W1990042464 endingPage "S39" @default.
• W1990042464 startingPage "S38" @default.
• W1990042464 abstract "Liposomes are non toxic and biodegradable lipid vesicles, which are safe and effective adjuvants to induce Th1-skewed immune response. Therefore, the encapsulation of allergens into liposomes could be an attractive alternative for specific allergy immunotherapy. Previously, we obtained DPPC iposomes encapsulating purified allergens from Dermatophagoides siboney, with suitable stability and extremely reduced allergenicity. In this study, Balb/c mice were immunized with allergens ncapsulated into liposomes (LP) and the induced immune response was evaluated in comparison with allergens dissolved in PBS (PBSA) or adsorbed in Alum (AL). The use of Alum or Liposomes induced a strong allergen specific IgG response. However, total IgE serum levels in the AL group were very high, while levels found in LP group were not significantly different from the control group receiving only PBS. The IgG2a/IgG1 subclass ratio was raised in the LP group. Allergen specific IgE, as measured by PCA assay, was similar for LP and PBSA groups, and approximately the half of the reaction size found in AL group. After allergen challenge by inhalation route, peripheral blood and airway eosinophil counts increased significantly in AL, but not in LP group. Additionally, histopathological analysis of lung tissue sections obtained from challenged mice indicated a reduced cellular infiltration in mice immunized with liposomes. These results support the potential use of liposomal formulations for allergen vaccines." @default.
• W1990042464 created "2016-06-24" @default.
• W1990042464 creator A5001931176 @default.
• W1990042464 creator A5004234354 @default.
• W1990042464 creator A5014968582 @default.
• W1990042464 creator A5023550694 @default.
• W1990042464 creator A5026957116 @default.
• W1990042464 creator A5040844523 @default.
• W1990042464 creator A5058692526 @default.
• W1990042464 creator A5059266465 @default.
• W1990042464 creator A5059852997 @default.
• W1990042464 creator A5070624062 @default.
• W1990042464 creator A5073839801 @default.
• W1990042464 creator A5074791701 @default.
• W1990042464 creator A5083549173 @default.
• W1990042464 creator A5087925860 @default.
• W1990042464 date "2006-04-01" @default.
• W1990042464 modified "2023-10-18" @default.
• W1990042464 title "Modulation of the specific allergic response by mite allergens encapsulated into liposomes" @default.
• W1990042464 cites W1970502718 @default.
• W1990042464 cites W1990977464 @default.
• W1990042464 cites W2020873921 @default.
• W1990042464 cites W2033232206 @default.
• W1990042464 cites W2120289228 @default.
• W1990042464 doi "https://doi.org/10.1016/j.vaccine.2005.01.112" @default.
• W1990042464 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16823918" @default.
• W1990042464 hasPublicationYear "2006" @default.
• W1990042464 type Work @default.
• W1990042464 sameAs 1990042464 @default.
• W1990042464 citedByCount "8" @default.
• W1990042464 countsByYear W19900424642012 @default.
• W1990042464 countsByYear W19900424642013 @default.
• W1990042464 countsByYear W19900424642014 @default.
• W1990042464 countsByYear W19900424642015 @default.
• W1990042464 countsByYear W19900424642017 @default.
• W1990042464 countsByYear W19900424642020 @default.
• W1990042464 crossrefType "journal-article" @default.
• W1990042464 hasAuthorship W1990042464A5001931176 @default.
• W1990042464 hasAuthorship W1990042464A5004234354 @default.
• W1990042464 hasAuthorship W1990042464A5014968582 @default.
• W1990042464 hasAuthorship W1990042464A5023550694 @default.
• W1990042464 hasAuthorship W1990042464A5026957116 @default.
• W1990042464 hasAuthorship W1990042464A5040844523 @default.
• W1990042464 hasAuthorship W1990042464A5058692526 @default.
• W1990042464 hasAuthorship W1990042464A5059266465 @default.
• W1990042464 hasAuthorship W1990042464A5059852997 @default.
• W1990042464 hasAuthorship W1990042464A5070624062 @default.
• W1990042464 hasAuthorship W1990042464A5073839801 @default.
• W1990042464 hasAuthorship W1990042464A5074791701 @default.
• W1990042464 hasAuthorship W1990042464A5083549173 @default.
• W1990042464 hasAuthorship W1990042464A5087925860 @default.
• W1990042464 hasConcept C141105273 @default.
• W1990042464 hasConcept C159654299 @default.
• W1990042464 hasConcept C178790620 @default.
• W1990042464 hasConcept C185154212 @default.
• W1990042464 hasConcept C185592680 @default.
• W1990042464 hasConcept C203014093 @default.
• W1990042464 hasConcept C207480886 @default.
• W1990042464 hasConcept C2776042228 @default.
• W1990042464 hasConcept C2776953665 @default.
• W1990042464 hasConcept C2777037409 @default.
• W1990042464 hasConcept C2780510475 @default.
• W1990042464 hasConcept C2780924562 @default.
• W1990042464 hasConcept C55493867 @default.
• W1990042464 hasConcept C71924100 @default.
• W1990042464 hasConcept C8891405 @default.
• W1990042464 hasConceptScore W1990042464C141105273 @default.
• W1990042464 hasConceptScore W1990042464C159654299 @default.
• W1990042464 hasConceptScore W1990042464C178790620 @default.
• W1990042464 hasConceptScore W1990042464C185154212 @default.
• W1990042464 hasConceptScore W1990042464C185592680 @default.
• W1990042464 hasConceptScore W1990042464C203014093 @default.
• W1990042464 hasConceptScore W1990042464C207480886 @default.
• W1990042464 hasConceptScore W1990042464C2776042228 @default.
• W1990042464 hasConceptScore W1990042464C2776953665 @default.
• W1990042464 hasConceptScore W1990042464C2777037409 @default.
• W1990042464 hasConceptScore W1990042464C2780510475 @default.
• W1990042464 hasConceptScore W1990042464C2780924562 @default.
• W1990042464 hasConceptScore W1990042464C55493867 @default.
• W1990042464 hasConceptScore W1990042464C71924100 @default.
• W1990042464 hasConceptScore W1990042464C8891405 @default.
• W1990042464 hasLocation W19900424641 @default.
• W1990042464 hasLocation W19900424642 @default.
• W1990042464 hasOpenAccess W1990042464 @default.
• W1990042464 hasPrimaryLocation W19900424641 @default.
• W1990042464 hasRelatedWork W1538507717 @default.
• W1990042464 hasRelatedWork W1990042464 @default.
• W1990042464 hasRelatedWork W2009993815 @default.
• W1990042464 hasRelatedWork W2014471812 @default.
• W1990042464 hasRelatedWork W2083087446 @default.
• W1990042464 hasRelatedWork W2266295269 @default.
• W1990042464 hasRelatedWork W2576763337 @default.
• W1990042464 hasRelatedWork W2611818413 @default.
• W1990042464 hasRelatedWork W3047615353 @default.
• W1990042464 hasRelatedWork W4283364380 @default.
• W1990042464 hasVolume "24" @default.
• W1990042464 isParatext "false" @default.
• W1990042464 isRetracted "false" @default.

• next