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- W1990060712 abstract "We have studied 23 human B cell lines for TNFα receptor reactivities and TNF secretion. High affinity TNFα receptors with a wide range of 200 to 7200 receptor sites/cell and an average kD of ~10−10M were detected in 22 of 23 cell lines. Following activation with the tumor promoter teleocidin, changes in TNFα receptor binding were classified into three categories: (I) Downregulation of TNFα receptors (n = 15); (II) Upregulation of TNFα receptors (n = 5); and (III). No change of TNFα receptor binding (n = 3). Constitutive secretion of TNF was detected in 2 cell lines only, and teleocidin triggered TNF secretion in an additional 10 cell lines in category I. Although this suggests possible association between TNFα receptor downregulation and secreted TNF, 48-hr kinetic studies demonstrated that TNFα receptors were downregulated at ~1 hr after activation with teleocidin, whereas TNF secretion was detected only at 24 hr. TNFα receptor regulation did not seem to be influenced by secreted IL-1 and/or B cell IL-2-like molecule as well, but correlates with coexpression of IL-1 and IL-2 receptors. Dissecting the complexity between these three types of lymphokine receptors and their corresponding lymphokines suggest that TNFα receptor regulation is influenced by IL-2 receptors and/or IL-1 receptors coexpressed on the same cell, and that cross-talk between B cell lymphokine receptors exists." @default.
- W1990060712 created "2016-06-24" @default.
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- W1990060712 date "1990-02-01" @default.
- W1990060712 modified "2023-10-18" @default.
- W1990060712 title "Differential effects of teleocidin on TNFα receptor regulation in human B cell lines: Relationship to coexpression of IL-2 and IL-1 receptors and to lymphokine secretion" @default.
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- W1990060712 doi "https://doi.org/10.1016/0008-8749(90)90101-v" @default.
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