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- W1990067922 abstract "The cellular and molecular mechanisms involved in many abnormalities described in Systemic Lupus Erythematosus (SLE) are still unclear. Some of these abnormalities referred to the hyperactivation of T lymphocytes and the enhanced secretion of MMP-9 by peripheral blood mononuclear cells (PBMCs). Therefore, in this paper we investigated the potential role of CD147 molecule in these abnormalities. Our results demonstrated that CD147 molecule is overexpressed on CD3+T lymphocytes from SLE patients when compared with CD3+T lymphocytes from healthy donors. Monoclonal anti-CD147 antibodies, MEM-M6/1 clone, were able to inhibit protein tyrosine phosphorylation only in CD3 x CD28 costimulated T lymphocytes from SLE patients. However, this monoclonal antibody was unable to inhibit the enhanced activity of MMP-9 secreted by SLE PBMCs." @default.
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- W1990067922 date "2007-03-01" @default.
- W1990067922 modified "2023-10-17" @default.
- W1990067922 title "Roles of CD147 on T lymphocytes activation and MMP-9 secretion in Systemic Lupus Erythematosus" @default.
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- W1990067922 doi "https://doi.org/10.1111/j.1582-4934.2007.00022.x" @default.
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