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- W1990069109 abstract "The neurogenic niche within the subgranular zone (SGZ) of the dentate gyrus is a source of new neurons throughout life. Interestingly, SGZ proliferative capacity is regulated by both physiological and pathophysiological conditions. One outstanding question involves the molecular mechanisms that regulate both basal and inducible adult neurogenesis. Here, we examined the role of the MAPK-regulated kinases, mitogen- and stress-activated kinase (MSK)1 and MSK2. as regulators of dentate gyrus SGZ progenitor cell proliferation and neurogenesis. Under basal conditions, MSK1/2 null mice exhibited significantly reduced progenitor cell proliferation capacity and a corollary reduction in the number of doublecortin (DCX)-positive immature neurons. Strikingly, seizure-induced progenitor proliferation was totally blocked in MSK1/2 null mice. This blunting of cell proliferation in MSK1/2 null mice was partially reversed by forskolin infusion, indicating that the inducible proliferative capacity of the progenitor cell population was intact. Furthermore, in MSK1/2 null mice, DCX-positive immature neurons exhibited reduced neurite arborization. Together, these data reveal a critical role for MSK1/2 as regulators of both basal and activity-dependent progenitor cell proliferation and morphological maturation in the SGZ." @default.
- W1990069109 created "2016-06-24" @default.
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- W1990069109 date "2012-10-25" @default.
- W1990069109 modified "2023-10-16" @default.
- W1990069109 title "Mitogen- and stress-activated kinases regulate progenitor cell proliferation and neuron development in the adult dentate gyrus" @default.
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- W1990069109 cites W1912689628 @default.
- W1990069109 cites W1948207118 @default.
- W1990069109 cites W1964887620 @default.
- W1990069109 cites W1968656579 @default.
- W1990069109 cites W1972893985 @default.
- W1990069109 cites W1982437447 @default.
- W1990069109 cites W1995188451 @default.
- W1990069109 cites W1998977808 @default.
- W1990069109 cites W2001324348 @default.
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- W1990069109 cites W2017285865 @default.
- W1990069109 cites W2018896819 @default.
- W1990069109 cites W2021461047 @default.
- W1990069109 cites W2026393786 @default.
- W1990069109 cites W2027673318 @default.
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- W1990069109 doi "https://doi.org/10.1111/jnc.12035" @default.
- W1990069109 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3575744" @default.
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