FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990072589> ?p ?o ?g. }

• W1990072589 endingPage "350" @default.
• W1990072589 startingPage "343" @default.
• W1990072589 abstract "The objective of this study was to investigate CD163+ macrophages in the synovial membrane of patients with spondyloarthropathy (SpA). Immunohistochemistry was performed on synovium of 17 SpA and 18 rheumatoid arthritis (RA) patients, on colonic biopsies of 16 SpA patients and ten healthy controls, and on paired synovial biopsies of eight SpA patients, before and after anti-TNFalpha therapy. Phenotype and cytokine production were analysed by flow cytometry. CD163+ macrophages were increased in the synovial lining and sublining in SpA versus RA, as well as in colonic lamina propria in SpA versus controls. The number of CD163+ macrophages in the synovial sublining correlated with C-reactive protein levels and erythrocyte sedimentation rate. Paralleling the increase of CD163, HLA-DR was increased in the synovial lining and sublining of SpA. In contrast, the co-stimulatory molecules CD80 and CD86 and the dendritic cell markers CD1a and CD83 were scarce in SpA synovium. Flow cytometry indicated that CD163+ macrophages expressed high levels of HLA-DR and could produce in vitro tumour necrosis factor alpha (TNFalpha) but not interleukin-10 (IL-10). Finally, anti-TNFalpha therapy in vivo induced a decrease of CD163+ macrophages in the synovial lining and sublining. In conclusion, macrophages expressing the scavenger receptor CD163 are increased in synovium and in colonic mucosa in SpA, highlighting the relationship between joint and gut in this disease. The correlation with inflammatory parameters, the expression of HLA-DR, the production of TNFalpha but not IL-10, and the reduction by anti-TNFalpha therapy support a role for CD163+ macrophages in the synovial inflammation in SpA." @default.
• W1990072589 created "2016-06-24" @default.
• W1990072589 creator A5018782895 @default.
• W1990072589 creator A5024764499 @default.
• W1990072589 creator A5046625022 @default.
• W1990072589 creator A5053979605 @default.
• W1990072589 creator A5069497341 @default.
• W1990072589 creator A5077220554 @default.
• W1990072589 creator A5085069467 @default.
• W1990072589 creator A5085079548 @default.
• W1990072589 date "2002-01-01" @default.
• W1990072589 modified "2023-09-27" @default.
• W1990072589 title "Macrophages expressing the scavenger receptor CD163: a link between immune alterations of the gut and synovial inflammation in spondyloarthropathy" @default.
• W1990072589 cites W1535567348 @default.
• W1990072589 cites W1960832851 @default.
• W1990072589 cites W1975933306 @default.
• W1990072589 cites W1987224476 @default.
• W1990072589 cites W2000539788 @default.
• W1990072589 cites W2021561853 @default.
• W1990072589 cites W2034066083 @default.
• W1990072589 cites W2037976962 @default.
• W1990072589 cites W2051880698 @default.
• W1990072589 cites W2057817955 @default.
• W1990072589 cites W2066246367 @default.
• W1990072589 cites W2067249142 @default.
• W1990072589 cites W2070904260 @default.
• W1990072589 cites W2073177499 @default.
• W1990072589 cites W2073446457 @default.
• W1990072589 cites W2097095958 @default.
• W1990072589 cites W2098252815 @default.
• W1990072589 cites W2105296887 @default.
• W1990072589 cites W2105794709 @default.
• W1990072589 cites W2106036990 @default.
• W1990072589 cites W2126299335 @default.
• W1990072589 cites W2135152076 @default.
• W1990072589 cites W2137109050 @default.
• W1990072589 cites W2138671287 @default.
• W1990072589 cites W2140235660 @default.
• W1990072589 cites W2145893204 @default.
• W1990072589 cites W2152348310 @default.
• W1990072589 cites W2152887115 @default.
• W1990072589 cites W4313347857 @default.
• W1990072589 doi "https://doi.org/10.1002/path.1044" @default.
• W1990072589 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11857499" @default.
• W1990072589 hasPublicationYear "2002" @default.
• W1990072589 type Work @default.
• W1990072589 sameAs 1990072589 @default.
• W1990072589 citedByCount "171" @default.
• W1990072589 countsByYear W19900725892012 @default.
• W1990072589 countsByYear W19900725892013 @default.
• W1990072589 countsByYear W19900725892014 @default.
• W1990072589 countsByYear W19900725892015 @default.
• W1990072589 countsByYear W19900725892016 @default.
• W1990072589 countsByYear W19900725892017 @default.
• W1990072589 countsByYear W19900725892018 @default.
• W1990072589 countsByYear W19900725892019 @default.
• W1990072589 countsByYear W19900725892020 @default.
• W1990072589 countsByYear W19900725892021 @default.
• W1990072589 countsByYear W19900725892022 @default.
• W1990072589 countsByYear W19900725892023 @default.
• W1990072589 crossrefType "journal-article" @default.
• W1990072589 hasAuthorship W1990072589A5018782895 @default.
• W1990072589 hasAuthorship W1990072589A5024764499 @default.
• W1990072589 hasAuthorship W1990072589A5046625022 @default.
• W1990072589 hasAuthorship W1990072589A5053979605 @default.
• W1990072589 hasAuthorship W1990072589A5069497341 @default.
• W1990072589 hasAuthorship W1990072589A5077220554 @default.
• W1990072589 hasAuthorship W1990072589A5085069467 @default.
• W1990072589 hasAuthorship W1990072589A5085079548 @default.
• W1990072589 hasConcept C142724271 @default.
• W1990072589 hasConcept C17991360 @default.
• W1990072589 hasConcept C202751555 @default.
• W1990072589 hasConcept C203014093 @default.
• W1990072589 hasConcept C2775858924 @default.
• W1990072589 hasConcept C2776447464 @default.
• W1990072589 hasConcept C2776914184 @default.
• W1990072589 hasConcept C2777575956 @default.
• W1990072589 hasConcept C2777652487 @default.
• W1990072589 hasConcept C2778690821 @default.
• W1990072589 hasConcept C2779244956 @default.
• W1990072589 hasConcept C553184892 @default.
• W1990072589 hasConcept C55493867 @default.
• W1990072589 hasConcept C71924100 @default.
• W1990072589 hasConcept C86803240 @default.
• W1990072589 hasConceptScore W1990072589C142724271 @default.
• W1990072589 hasConceptScore W1990072589C17991360 @default.
• W1990072589 hasConceptScore W1990072589C202751555 @default.
• W1990072589 hasConceptScore W1990072589C203014093 @default.
• W1990072589 hasConceptScore W1990072589C2775858924 @default.
• W1990072589 hasConceptScore W1990072589C2776447464 @default.
• W1990072589 hasConceptScore W1990072589C2776914184 @default.
• W1990072589 hasConceptScore W1990072589C2777575956 @default.
• W1990072589 hasConceptScore W1990072589C2777652487 @default.
• W1990072589 hasConceptScore W1990072589C2778690821 @default.
• W1990072589 hasConceptScore W1990072589C2779244956 @default.
• W1990072589 hasConceptScore W1990072589C553184892 @default.
• W1990072589 hasConceptScore W1990072589C55493867 @default.
• W1990072589 hasConceptScore W1990072589C71924100 @default.

• next