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- W1990073408 abstract "Somatostatin receptors (sst) mediate the numerous physiological actions (e.g., aspects of growth, development, and metabolism) of the somatostatin family of peptides. In this study, we used rainbow trout (Oncorhynchus mykiss) to establish the pattern of sst subtype 1A, 1B, and 2 mRNA expression in selected tissues (optic tectum of brain, endocrine pancreas, and liver) and to evaluate nutritional regulation of sst expression. Quantitative real-time reverse transcription-PCR, sensitive to less than 100 copies, revealed that sst1s and sst2 was differentially expressed, both in terms of distribution among the tissues of study and in terms of relative abundance within a particular tissue. Under normal physiological (fed) conditions, sst1B levels were two times greater than those of sst1A in all tissues examined and levels of sst2 were 2-5 times greater those of sst1B, except in optic tectum, in which sst1B and sst2 mRNA levels appeared equal. Nutritional state modulated the pattern of sst1 and sst2 mRNAs expression. Fasting for 2 or 6 weeks reduced the expression of sst mRNAs in optic tectum; whereas, fasting increased the expression of sst mRNAs in both pancreas and liver. Re-feeding animals for 2 weeks following a 4-week fast restored mRNA levels to near those in tissues from animals which were fed continuously. These findings indicate that the pattern of sst expression in optic tectum, pancreas, and liver is regulated by nutritional state." @default.
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- W1990073408 date "2004-12-01" @default.
- W1990073408 modified "2023-09-23" @default.
- W1990073408 title "Somatostatin receptor subtype 1 and subtype 2 mRNA expression is regulated by nutritional state in rainbow trout (Oncorhynchus mykiss)" @default.
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- W1990073408 doi "https://doi.org/10.1016/j.ygcen.2004.09.008" @default.
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