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- W1990073837 abstract "Three clinically important mutations; Two of the methyltetrahydrofolate reductase (MTHFR) gene namely C677T, A1298C, and insertion/deletion (I/D) polymorphism of the angiotensin converting enzyme (ACE) gene are reported to be associated with various pathological conditions. This study is planned in order to etaulave the association of genetic polymorphisms related to these genes with hypertension. These polymorphisms can be utilized as biomarkers for susceptibility and severity of the disorder with a potential impact on diagnosis and management. Participants included 117 cases (78 males and 39 females) with an age mean ±SD of 50.93 ± 15.43 years. They were hospitalized for hypertensive complications including cardiac affection (64.9%) and renal dysfunction (17.9%) or strokes (20%). For comparison, 169, age and sex matched; with an age mean ±SD of 47.65 ± 11.15 normal healthy unrelated subjects (78 males and 91 females) were taken from the same locality as controls. For all participants, DNA was extracted followed by real-time PCR amplifications for characterization of genotypes and alleles related to MTHFR C677T, A1298C and ACE I/D gene polymorphisms. Compared to controls, cases showed significantly higher frequency of the heterozygous genotypes of MTHFR AC (52.1% vs. 36.5%, p Keywords : Methylenetetrahydrofolate reductase (MTHFR) - hypertension - Saudi –ACE- genetic polymorphisms" @default.
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- W1990073837 date "2011-06-23" @default.
- W1990073837 modified "2023-09-26" @default.
- W1990073837 title "Polymorophisms in MTHF and ace genes and the association with hypertension among Saudi population from Qassim region" @default.
- W1990073837 doi "https://doi.org/10.4314/ejbmb.v29i1.67382" @default.
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