FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990074743> ?p ?o ?g. }

• W1990074743 endingPage "522" @default.
• W1990074743 startingPage "516" @default.
• W1990074743 abstract "Despite efforts to improve surgical, radiologic, and chemotherapeutic strategies, the outcome of patients with glioblastoma (GBM) is still poor. Polo-like kinase 1 (PLK1) is a serine/threonine kinase that plays key roles in cell cycle control and has been associated with tumor growth and prognosis. Here, we aimed at testing the radiosensitizing effects of the PLK1 inhibitor BI 2536 on eight GBM cell lines. For cell cycle analysis, T98G, U251, U343 MG-a, LN319, SF188, U138 MG, and U87 MG cell lines were treated with 10, 50, or 100 nM of BI 2536 for 24 hours. In addition, cell cultures exposed to BI 2536 50 nM for 24 hours were irradiated with γ-rays from 60Cobalt source at final doses of 2, 4, and 6 Gy. Combinatorial effects were evaluated through proliferation and clonogenic capacity assays. Treatment with BI 2536 caused mitotic arrest after 24 hours, and increased apoptosis in GBM cells. Moreover, our results demonstrate that pretreatment with this drug sensitized six out of seven GBM cell lines to different doses of γ-irradiation as shown by decreased growth and abrogation of colony-formation capacity. Our data suggest that PLK1 blockage has a radiosensitizing effect on GBM, which could improve treatment strategies for this devastating tumor." @default.
• W1990074743 created "2016-06-24" @default.
• W1990074743 creator A5013080591 @default.
• W1990074743 creator A5027221850 @default.
• W1990074743 creator A5029216107 @default.
• W1990074743 creator A5071063454 @default.
• W1990074743 creator A5089350518 @default.
• W1990074743 creator A5089665676 @default.
• W1990074743 creator A5091871598 @default.
• W1990074743 date "2013-09-01" @default.
• W1990074743 modified "2023-10-01" @default.
• W1990074743 title "Inhibition of Polo-Like Kinase 1 Induces Cell Cycle Arrest and Sensitizes Glioblastoma Cells to Ionizing Radiation" @default.
• W1990074743 cites W1600720931 @default.
• W1990074743 cites W163326248 @default.
• W1990074743 cites W1964068520 @default.
• W1990074743 cites W1970112133 @default.
• W1990074743 cites W1975549758 @default.
• W1990074743 cites W1982096708 @default.
• W1990074743 cites W1982304115 @default.
• W1990074743 cites W1984949180 @default.
• W1990074743 cites W1993941887 @default.
• W1990074743 cites W2001500829 @default.
• W1990074743 cites W2002881571 @default.
• W1990074743 cites W2004207510 @default.
• W1990074743 cites W2012543836 @default.
• W1990074743 cites W2017014948 @default.
• W1990074743 cites W2019875881 @default.
• W1990074743 cites W2021336231 @default.
• W1990074743 cites W2027294184 @default.
• W1990074743 cites W2029108033 @default.
• W1990074743 cites W2037874673 @default.
• W1990074743 cites W2040870480 @default.
• W1990074743 cites W2051909570 @default.
• W1990074743 cites W2053133597 @default.
• W1990074743 cites W2058153393 @default.
• W1990074743 cites W2059095707 @default.
• W1990074743 cites W2059575225 @default.
• W1990074743 cites W2063806011 @default.
• W1990074743 cites W2072992526 @default.
• W1990074743 cites W2095280226 @default.
• W1990074743 cites W2107232024 @default.
• W1990074743 cites W2108268005 @default.
• W1990074743 cites W2111902584 @default.
• W1990074743 cites W2114135705 @default.
• W1990074743 cites W2115496571 @default.
• W1990074743 cites W2132834292 @default.
• W1990074743 cites W2138348020 @default.
• W1990074743 cites W2146212019 @default.
• W1990074743 cites W2146756681 @default.
• W1990074743 cites W2155880350 @default.
• W1990074743 cites W2156570047 @default.
• W1990074743 cites W2170175754 @default.
• W1990074743 cites W2171881796 @default.
• W1990074743 cites W2319917786 @default.
• W1990074743 cites W2333316232 @default.
• W1990074743 doi "https://doi.org/10.1089/cbr.2012.1415" @default.
• W1990074743 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3741430" @default.
• W1990074743 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23713868" @default.
• W1990074743 hasPublicationYear "2013" @default.
• W1990074743 type Work @default.
• W1990074743 sameAs 1990074743 @default.
• W1990074743 citedByCount "22" @default.
• W1990074743 countsByYear W19900747432015 @default.
• W1990074743 countsByYear W19900747432016 @default.
• W1990074743 countsByYear W19900747432017 @default.
• W1990074743 countsByYear W19900747432018 @default.
• W1990074743 countsByYear W19900747432019 @default.
• W1990074743 countsByYear W19900747432020 @default.
• W1990074743 countsByYear W19900747432021 @default.
• W1990074743 countsByYear W19900747432022 @default.
• W1990074743 countsByYear W19900747432023 @default.
• W1990074743 crossrefType "journal-article" @default.
• W1990074743 hasAuthorship W1990074743A5013080591 @default.
• W1990074743 hasAuthorship W1990074743A5027221850 @default.
• W1990074743 hasAuthorship W1990074743A5029216107 @default.
• W1990074743 hasAuthorship W1990074743A5071063454 @default.
• W1990074743 hasAuthorship W1990074743A5089350518 @default.
• W1990074743 hasAuthorship W1990074743A5089665676 @default.
• W1990074743 hasAuthorship W1990074743A5091871598 @default.
• W1990074743 hasBestOaLocation W19900747432 @default.
• W1990074743 hasConcept C105696609 @default.
• W1990074743 hasConcept C111337013 @default.
• W1990074743 hasConcept C117262875 @default.
• W1990074743 hasConcept C121332964 @default.
• W1990074743 hasConcept C146276462 @default.
• W1990074743 hasConcept C18231593 @default.
• W1990074743 hasConcept C184235292 @default.
• W1990074743 hasConcept C185544564 @default.
• W1990074743 hasConcept C185592680 @default.
• W1990074743 hasConcept C190283241 @default.
• W1990074743 hasConcept C29537977 @default.
• W1990074743 hasConcept C502942594 @default.
• W1990074743 hasConcept C54355233 @default.
• W1990074743 hasConcept C55493867 @default.
• W1990074743 hasConcept C62112901 @default.
• W1990074743 hasConcept C71924100 @default.
• W1990074743 hasConcept C81885089 @default.
• W1990074743 hasConcept C84815855 @default.

• next