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• W1990086104 abstract "The determination of lacunar-canalicular permeability is essential for understanding local fluid flow in bone, which may indicate how bone senses changes in the mechanical environment to regulate mechano-adaptation. The estimates of lacunar-canalicular permeability found in the literature vary by up to eight orders of magnitude, and age-related permeability changes have not been measured in non-osteonal mouse bone. The objective of this study is to use a poroelastic approach based on nanoindentation data to characterize lacunar-canalicular permeability in murine bone as a function of age. Nine wild type C57BL/6 mice of different ages (2, 7 and 12 months) were used. Three tibiae from each age group were embedded in epoxy resin, cut in half and indented in the longitudinal direction in the mid-cortex using two spherical fluid indenter tips (R=238 μm and 500 μm). Results suggest that the lacunar-canalicular intrinsic permeability of mouse bone decreases from 2 to 7 months, with no significant changes from 7 to 12 months. The large indenter tip imposed larger contact sizes and sampled larger ranges of permeabilities, particularly for the old bone. This age-related difference in the distribution was not seen for indents with the smaller radius tip. We conclude that the small tip effectively measured lacunar-canalicular permeability, while larger tip indents were influenced by vascular permeability. Exploring the age-related changes in permeability of bone measured by nanoindentation will lead to a better understanding of the role of fluid flow in mechano-transduction. This understanding may help indicate alterations in bone adaptation and remodeling." @default.
• W1990086104 created "2016-06-24" @default.
• W1990086104 creator A5017037308 @default.
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• W1990086104 date "2014-03-01" @default.
• W1990086104 modified "2023-10-14" @default.
• W1990086104 title "Age-related changes in mouse bone permeability" @default.
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• W1990086104 doi "https://doi.org/10.1016/j.jbiomech.2013.12.020" @default.
• W1990086104 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24433671" @default.
• W1990086104 hasPublicationYear "2014" @default.
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