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- W1990110014 abstract "1. Phenylbutazone (5 mM) inhibits incorporation of [1-14C]glucosamine and [14c]leucine into acid precipitable protein by rat intestinal slices. 2. Inhibition of [1-14C]glucosamine incorporation was independent of medium glucosamine concentration. 3. Phenylbutazone inhibited [1-14C]glucosamine incorporation by cycloheximide-treated slices. Reduced [1-14C]glucosamine incorporation did not result solely from inhibition of protein synthesis. 4. Analysis of mucosal acid soluble intermediate labelling revealed an increase in glucosamine and a reduction in all hexosamine intermediates following phenylbutazone. 5. These effects closely parallel previous experience with sodium salicylate and may represent a common basis for their adverse gastrointestinal effects." @default.
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- W1990110014 date "1974-02-01" @default.
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- W1990110014 title "Synthesis of intestinal glycoproteins inhibitions of [1-14C]glucosamine incorporation by phenylbutazone in vitro" @default.
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- W1990110014 doi "https://doi.org/10.1016/0304-4165(74)90294-3" @default.
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