FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990120178> ?p ?o ?g. }

• W1990120178 endingPage "1832" @default.
• W1990120178 startingPage "1827" @default.
• W1990120178 abstract "An integrated QSAR/molecular modeling study is carried out on a series of baclofen analogues with the aim of addressing the role of their aromatic moiety in GABA(B) receptor binding and activation. The strong correlation found between electronic descriptors (HOMO and LUMO orbital energies) and the biological activity expressed as receptor binding is discussed also on the basis of available experimental mutagenesis data and of the results obtained from homology modeling of GABA(B) receptor. In particular, it can be inferred from the QSAR analysis that the ability of being involved in aromatic-aromatic pi interaction is the distinctive feature of the p-chlorophenyl moiety of baclofen. This conclusion is confirmed by homology modeling and docking studies which indicate that the p-chlorophenyl moiety of baclofen is disposed into a pocket formed by Tyr366 and Tyr395. These results are discussed in terms of mechanism of GABA(B) activation promoted by baclofen or GABA." @default.
• W1990120178 created "2016-06-24" @default.
• W1990120178 creator A5003129691 @default.
• W1990120178 creator A5045044750 @default.
• W1990120178 creator A5045663508 @default.
• W1990120178 creator A5077010876 @default.
• W1990120178 date "2001-04-28" @default.
• W1990120178 modified "2023-09-23" @default.
• W1990120178 title "QSAR and Molecular Modeling Studies of Baclofen Analogues as GABA_B Agonists. Insights into the Role of the Aromatic Moiety in GABA_B Binding and Activation" @default.
• W1990120178 cites W1654156243 @default.
• W1990120178 cites W1998097979 @default.
• W1990120178 cites W1998543478 @default.
• W1990120178 cites W2007798373 @default.
• W1990120178 cites W2013178404 @default.
• W1990120178 cites W2049914524 @default.
• W1990120178 cites W2061650979 @default.
• W1990120178 cites W2083954196 @default.
• W1990120178 cites W2091977217 @default.
• W1990120178 cites W2094186244 @default.
• W1990120178 cites W2100662386 @default.
• W1990120178 cites W2122038035 @default.
• W1990120178 cites W2157959080 @default.
• W1990120178 cites W2167767264 @default.
• W1990120178 cites W2170006871 @default.
• W1990120178 doi "https://doi.org/10.1021/jm0100133" @default.
• W1990120178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11356116" @default.
• W1990120178 hasPublicationYear "2001" @default.
• W1990120178 type Work @default.
• W1990120178 sameAs 1990120178 @default.
• W1990120178 citedByCount "54" @default.
• W1990120178 countsByYear W19901201782013 @default.
• W1990120178 countsByYear W19901201782014 @default.
• W1990120178 countsByYear W19901201782015 @default.
• W1990120178 countsByYear W19901201782016 @default.
• W1990120178 countsByYear W19901201782017 @default.
• W1990120178 countsByYear W19901201782018 @default.
• W1990120178 countsByYear W19901201782019 @default.
• W1990120178 countsByYear W19901201782020 @default.
• W1990120178 countsByYear W19901201782021 @default.
• W1990120178 countsByYear W19901201782022 @default.
• W1990120178 crossrefType "journal-article" @default.
• W1990120178 hasAuthorship W1990120178A5003129691 @default.
• W1990120178 hasAuthorship W1990120178A5045044750 @default.
• W1990120178 hasAuthorship W1990120178A5045663508 @default.
• W1990120178 hasAuthorship W1990120178A5077010876 @default.
• W1990120178 hasConcept C101027131 @default.
• W1990120178 hasConcept C14158195 @default.
• W1990120178 hasConcept C159110408 @default.
• W1990120178 hasConcept C164126121 @default.
• W1990120178 hasConcept C168258287 @default.
• W1990120178 hasConcept C169627665 @default.
• W1990120178 hasConcept C170493617 @default.
• W1990120178 hasConcept C178790620 @default.
• W1990120178 hasConcept C178910836 @default.
• W1990120178 hasConcept C181199279 @default.
• W1990120178 hasConcept C185592680 @default.
• W1990120178 hasConcept C2776568683 @default.
• W1990120178 hasConcept C2778938600 @default.
• W1990120178 hasConcept C2781201050 @default.
• W1990120178 hasConcept C32909587 @default.
• W1990120178 hasConcept C41685203 @default.
• W1990120178 hasConcept C55493867 @default.
• W1990120178 hasConcept C71240020 @default.
• W1990120178 hasConcept C71924100 @default.
• W1990120178 hasConceptScore W1990120178C101027131 @default.
• W1990120178 hasConceptScore W1990120178C14158195 @default.
• W1990120178 hasConceptScore W1990120178C159110408 @default.
• W1990120178 hasConceptScore W1990120178C164126121 @default.
• W1990120178 hasConceptScore W1990120178C168258287 @default.
• W1990120178 hasConceptScore W1990120178C169627665 @default.
• W1990120178 hasConceptScore W1990120178C170493617 @default.
• W1990120178 hasConceptScore W1990120178C178790620 @default.
• W1990120178 hasConceptScore W1990120178C178910836 @default.
• W1990120178 hasConceptScore W1990120178C181199279 @default.
• W1990120178 hasConceptScore W1990120178C185592680 @default.
• W1990120178 hasConceptScore W1990120178C2776568683 @default.
• W1990120178 hasConceptScore W1990120178C2778938600 @default.
• W1990120178 hasConceptScore W1990120178C2781201050 @default.
• W1990120178 hasConceptScore W1990120178C32909587 @default.
• W1990120178 hasConceptScore W1990120178C41685203 @default.
• W1990120178 hasConceptScore W1990120178C55493867 @default.
• W1990120178 hasConceptScore W1990120178C71240020 @default.
• W1990120178 hasConceptScore W1990120178C71924100 @default.
• W1990120178 hasIssue "11" @default.
• W1990120178 hasLocation W19901201781 @default.
• W1990120178 hasLocation W19901201782 @default.
• W1990120178 hasOpenAccess W1990120178 @default.
• W1990120178 hasPrimaryLocation W19901201781 @default.
• W1990120178 hasRelatedWork W1804425206 @default.
• W1990120178 hasRelatedWork W1990120178 @default.
• W1990120178 hasRelatedWork W1990180682 @default.
• W1990120178 hasRelatedWork W2016318508 @default.
• W1990120178 hasRelatedWork W2030067016 @default.
• W1990120178 hasRelatedWork W2048834258 @default.
• W1990120178 hasRelatedWork W2057931667 @default.
• W1990120178 hasRelatedWork W2076386220 @default.
• W1990120178 hasRelatedWork W2095743501 @default.
• W1990120178 hasRelatedWork W2169688334 @default.

• next