FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990125482> ?p ?o ?g. }

• W1990125482 endingPage "e67672" @default.
• W1990125482 startingPage "e67672" @default.
• W1990125482 abstract "The discovery of genetic or genomic markers plays a central role in the development of personalized medicine. A notable challenge exists when dealing with the high dimensionality of the data sets, as thousands of genes or millions of genetic variants are collected on a relatively small number of subjects. Traditional gene-wise selection methods using univariate analyses face difficulty to incorporate correlational, structural, or functional structures amongst the molecular measures. For microarray gene expression data, we first summarize solutions in dealing with 'large p, small n' problems, and then propose an integrative Bayesian variable selection (iBVS) framework for simultaneously identifying causal or marker genes and regulatory pathways. A novel partial least squares (PLS) g-prior for iBVS is developed to allow the incorporation of prior knowledge on gene-gene interactions or functional relationships. From the point view of systems biology, iBVS enables user to directly target the joint effects of multiple genes and pathways in a hierarchical modeling diagram to predict disease status or phenotype. The estimated posterior selection probabilities offer probabilitic and biological interpretations. Both simulated data and a set of microarray data in predicting stroke status are used in validating the performance of iBVS in a Probit model with binary outcomes. iBVS offers a general framework for effective discovery of various molecular biomarkers by combining data-based statistics and knowledge-based priors. Guidelines on making posterior inferences, determining Bayesian significance levels, and improving computational efficiencies are also discussed." @default.
• W1990125482 created "2016-06-24" @default.
• W1990125482 creator A5021376490 @default.
• W1990125482 creator A5021502220 @default.
• W1990125482 creator A5030528659 @default.
• W1990125482 creator A5033511047 @default.
• W1990125482 creator A5052596350 @default.
• W1990125482 creator A5081051831 @default.
• W1990125482 creator A5085481857 @default.
• W1990125482 date "2013-07-03" @default.
• W1990125482 modified "2023-09-30" @default.
• W1990125482 title "An Integrative Framework for Bayesian Variable Selection with Informative Priors for Identifying Genes and Pathways" @default.
• W1990125482 cites W1543012556 @default.
• W1990125482 cites W1567519924 @default.
• W1990125482 cites W1774711529 @default.
• W1990125482 cites W1827378692 @default.
• W1990125482 cites W1876352197 @default.
• W1990125482 cites W1964735403 @default.
• W1990125482 cites W1971213778 @default.
• W1990125482 cites W1971289666 @default.
• W1990125482 cites W1973325935 @default.
• W1990125482 cites W1975839276 @default.
• W1990125482 cites W1976209715 @default.
• W1990125482 cites W198876342 @default.
• W1990125482 cites W1991984435 @default.
• W1990125482 cites W1992045522 @default.
• W1990125482 cites W1995017987 @default.
• W1990125482 cites W1997108778 @default.
• W1990125482 cites W2007069447 @default.
• W1990125482 cites W2013901661 @default.
• W1990125482 cites W2014426141 @default.
• W1990125482 cites W2020389170 @default.
• W1990125482 cites W2028957796 @default.
• W1990125482 cites W2031644101 @default.
• W1990125482 cites W2031913033 @default.
• W1990125482 cites W2036183522 @default.
• W1990125482 cites W2047204673 @default.
• W1990125482 cites W2047554048 @default.
• W1990125482 cites W2049228615 @default.
• W1990125482 cites W2049974415 @default.
• W1990125482 cites W2050029156 @default.
• W1990125482 cites W2054699810 @default.
• W1990125482 cites W2060705109 @default.
• W1990125482 cites W2062833934 @default.
• W1990125482 cites W2068743483 @default.
• W1990125482 cites W2070659891 @default.
• W1990125482 cites W2081098333 @default.
• W1990125482 cites W2082516237 @default.
• W1990125482 cites W2085766216 @default.
• W1990125482 cites W2088538053 @default.
• W1990125482 cites W2095741373 @default.
• W1990125482 cites W2097758663 @default.
• W1990125482 cites W2099744219 @default.
• W1990125482 cites W2100835274 @default.
• W1990125482 cites W2101122849 @default.
• W1990125482 cites W2105882193 @default.
• W1990125482 cites W2106706098 @default.
• W1990125482 cites W2107321252 @default.
• W1990125482 cites W2108306139 @default.
• W1990125482 cites W2109363337 @default.
• W1990125482 cites W2111051773 @default.
• W1990125482 cites W2117135012 @default.
• W1990125482 cites W2117163583 @default.
• W1990125482 cites W2122236683 @default.
• W1990125482 cites W2122825543 @default.
• W1990125482 cites W2126815340 @default.
• W1990125482 cites W2129577681 @default.
• W1990125482 cites W2130410032 @default.
• W1990125482 cites W2133199783 @default.
• W1990125482 cites W2134394193 @default.
• W1990125482 cites W2138019504 @default.
• W1990125482 cites W2141660903 @default.
• W1990125482 cites W2144227498 @default.
• W1990125482 cites W2148534890 @default.
• W1990125482 cites W2151693816 @default.
• W1990125482 cites W2154947819 @default.
• W1990125482 cites W2157875785 @default.
• W1990125482 cites W2160667028 @default.
• W1990125482 cites W2162371443 @default.
• W1990125482 cites W2163555145 @default.
• W1990125482 cites W2169989696 @default.
• W1990125482 cites W2170414736 @default.
• W1990125482 cites W2172221156 @default.
• W1990125482 cites W3099090856 @default.
• W1990125482 cites W3101256146 @default.
• W1990125482 cites W314265539 @default.
• W1990125482 cites W4205337121 @default.
• W1990125482 cites W4241972798 @default.
• W1990125482 cites W4254630790 @default.
• W1990125482 cites W4292691288 @default.
• W1990125482 cites W4297900044 @default.
• W1990125482 cites W4300819821 @default.
• W1990125482 cites W4301861531 @default.
• W1990125482 cites W605074669 @default.
• W1990125482 cites W619744516 @default.
• W1990125482 doi "https://doi.org/10.1371/journal.pone.0067672" @default.
• W1990125482 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3700986" @default.
• W1990125482 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23844055" @default.

• next