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- W1990129042 abstract "Retinal amacrine cells of the same class in cyprinid fish are homotypically connected by gap junctions. The permeability of their gap junctions examined by the diffusion of Neurobiotin into neighboring amacrine cells under application of dopamine or cyclic nucleotides to elucidate whether electrical synapses between the cells are regulated by internal messengers. Neurobiotin injected intracellularly into amacrine cells in isolated retinas of goldfish, and passage currents through the electrical synapses investigated by dual whole-patch clamp recordings under similar application of their ligands. Control conditions led us to observe large passage currents between connected cells and adequate transjunctional conductance between the cells (2.02±0.82nS). Experimental results show that high level of intracellular cyclic AMP within examined cells block transfer of Neurobiotin and suppress electrical synapses between the neighboring cells. Transjunctional conductance between examined cells reduced to 0.23nS. However, dopamine, 8-bromo-cyclic AMP or high elevation of intracellular cyclic GMP leaves gap junction channels of the cells permeable to Neurobiotin as in the control level. Under application of dopamine (1.25±0.06nS), 8-bromo-cyclic AMP (1.79±0.51nS) or intracellular cyclic GMP (0.98±0.23nS), the transjunctional conductance also remains as in the control level. These results demonstrate that channel opening of gap junctions between cyprinid retinal amacrine cells is regulated by high level of intracellular cyclic AMP." @default.
- W1990129042 created "2016-06-24" @default.
- W1990129042 creator A5024685157 @default.
- W1990129042 date "2012-04-01" @default.
- W1990129042 modified "2023-10-17" @default.
- W1990129042 title "Suppression of electrical synapses between retinal amacrine cells of goldfish by intracellular cyclic-AMP" @default.
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- W1990129042 doi "https://doi.org/10.1016/j.brainres.2012.01.054" @default.
- W1990129042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22425185" @default.
- W1990129042 hasPublicationYear "2012" @default.
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