Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990131427> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W1990131427 endingPage "87" @default.
- W1990131427 startingPage "81" @default.
- W1990131427 abstract "This randomized, double-blind study investigated the effect of ciprostene, a stable epoprostenol (prostacyclin) analog in patients with peripheral vascular disease (PVD) characterized by ischemic ulcers. A total of 211 patients (106 ciprostene, 105 placebo) received IV infusions of ciprostene (120 ng/kg/min in 8-hour daily infusions for 7 days) or placebo. The two groups were comparable with regard to demographic data. Only 45% of the patients receiving ciprostene and 55% of the placebo patients completed the trial. The groups were similar in frequency of amputations, vascular surgery, and development of new ulcers. Among those who completed the trials an insignificantly higher percentage of patients receiving ciprostene had all ulcers heal completely. The reduction of ulcer size by at least 50% was higher in the ciprostene-treated group at month 4 (P = .005). Both ciprostene and placebo reduced the severity of a patient's rest pain. There was no difference in the ankle brachial index between the groups. Ciprostene induced a higher incidence of headache, nausea, and flushing during infusion when compared with the placebo group. The results confirmed inherent problems with studies in PVD, namely, scarcity of patients with ischemic ulcers, inclusion of severely ill patients leading to a high dropout rate, and a high placebo effect. Good tolerance and safety of ciprostene was documented in this patient population, and the therapeutic benefit was limited to partial reduction of ulcer size. Selection of patients with less advanced disease and a longer infusion of ciprostene may improve the clinical benefit of this agent." @default.
- W1990131427 created "2016-06-24" @default.
- W1990131427 creator A5086486615 @default.
- W1990131427 date "1991-01-01" @default.
- W1990131427 modified "2023-09-23" @default.
- W1990131427 title "The Effect of Ciprostene in Patients with Peripheral Vascular Disease (PVD) Characterized by Ischemic Ulcers" @default.
- W1990131427 cites W1977767314 @default.
- W1990131427 cites W1979101069 @default.
- W1990131427 cites W1987632597 @default.
- W1990131427 cites W2028715556 @default.
- W1990131427 cites W2046841614 @default.
- W1990131427 cites W2054031393 @default.
- W1990131427 cites W2062939365 @default.
- W1990131427 cites W2069763053 @default.
- W1990131427 cites W2072353010 @default.
- W1990131427 cites W2080536727 @default.
- W1990131427 cites W2090885589 @default.
- W1990131427 cites W2112657142 @default.
- W1990131427 cites W2443412821 @default.
- W1990131427 doi "https://doi.org/10.1002/j.1552-4604.1991.tb01891.x" @default.
- W1990131427 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2045533" @default.
- W1990131427 hasPublicationYear "1991" @default.
- W1990131427 type Work @default.
- W1990131427 sameAs 1990131427 @default.
- W1990131427 citedByCount "23" @default.
- W1990131427 countsByYear W19901314272014 @default.
- W1990131427 countsByYear W19901314272016 @default.
- W1990131427 countsByYear W19901314272018 @default.
- W1990131427 countsByYear W19901314272019 @default.
- W1990131427 countsByYear W19901314272022 @default.
- W1990131427 crossrefType "journal-article" @default.
- W1990131427 hasAuthorship W1990131427A5086486615 @default.
- W1990131427 hasConcept C120665830 @default.
- W1990131427 hasConcept C121332964 @default.
- W1990131427 hasConcept C126322002 @default.
- W1990131427 hasConcept C141071460 @default.
- W1990131427 hasConcept C142724271 @default.
- W1990131427 hasConcept C168563851 @default.
- W1990131427 hasConcept C204787440 @default.
- W1990131427 hasConcept C27081682 @default.
- W1990131427 hasConcept C2777466421 @default.
- W1990131427 hasConcept C2778640784 @default.
- W1990131427 hasConcept C2780580376 @default.
- W1990131427 hasConcept C2781103887 @default.
- W1990131427 hasConcept C2781128415 @default.
- W1990131427 hasConcept C2908647359 @default.
- W1990131427 hasConcept C42219234 @default.
- W1990131427 hasConcept C46762472 @default.
- W1990131427 hasConcept C535046627 @default.
- W1990131427 hasConcept C61511704 @default.
- W1990131427 hasConcept C71924100 @default.
- W1990131427 hasConcept C99454951 @default.
- W1990131427 hasConceptScore W1990131427C120665830 @default.
- W1990131427 hasConceptScore W1990131427C121332964 @default.
- W1990131427 hasConceptScore W1990131427C126322002 @default.
- W1990131427 hasConceptScore W1990131427C141071460 @default.
- W1990131427 hasConceptScore W1990131427C142724271 @default.
- W1990131427 hasConceptScore W1990131427C168563851 @default.
- W1990131427 hasConceptScore W1990131427C204787440 @default.
- W1990131427 hasConceptScore W1990131427C27081682 @default.
- W1990131427 hasConceptScore W1990131427C2777466421 @default.
- W1990131427 hasConceptScore W1990131427C2778640784 @default.
- W1990131427 hasConceptScore W1990131427C2780580376 @default.
- W1990131427 hasConceptScore W1990131427C2781103887 @default.
- W1990131427 hasConceptScore W1990131427C2781128415 @default.
- W1990131427 hasConceptScore W1990131427C2908647359 @default.
- W1990131427 hasConceptScore W1990131427C42219234 @default.
- W1990131427 hasConceptScore W1990131427C46762472 @default.
- W1990131427 hasConceptScore W1990131427C535046627 @default.
- W1990131427 hasConceptScore W1990131427C61511704 @default.
- W1990131427 hasConceptScore W1990131427C71924100 @default.
- W1990131427 hasConceptScore W1990131427C99454951 @default.
- W1990131427 hasIssue "1" @default.
- W1990131427 hasLocation W19901314271 @default.
- W1990131427 hasLocation W19901314272 @default.
- W1990131427 hasOpenAccess W1990131427 @default.
- W1990131427 hasPrimaryLocation W19901314271 @default.
- W1990131427 hasRelatedWork W2016053683 @default.
- W1990131427 hasRelatedWork W2047967234 @default.
- W1990131427 hasRelatedWork W2048862592 @default.
- W1990131427 hasRelatedWork W2116471168 @default.
- W1990131427 hasRelatedWork W2436963993 @default.
- W1990131427 hasRelatedWork W2439875401 @default.
- W1990131427 hasRelatedWork W3005847395 @default.
- W1990131427 hasRelatedWork W4253457320 @default.
- W1990131427 hasRelatedWork W2263645345 @default.
- W1990131427 hasRelatedWork W2948930061 @default.
- W1990131427 hasVolume "31" @default.
- W1990131427 isParatext "false" @default.
- W1990131427 isRetracted "false" @default.
- W1990131427 magId "1990131427" @default.
- W1990131427 workType "article" @default.