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- W199013206 abstract "Objective To study the new triterpene glycosides from sea cucumber Holothuria scabra with cytotoxic activity. Methods Triterpene glycosides from H. scabra were separated and purified by chromatography on DA-101, silica gel, and reversed-phase silica gel column, as well as RP-HPLC. Their structures were elucidated on the basis of spectral data and chemical evidence. Results Three triterpene glycosides were identified as scabraside D (1), fuscocineroside C (2), and 24-dehydroechinoside A (3). Their inhibition on P-388, A549, MKN-28, HCT116, and MCF-7 cells were significant. Conclusion Scabraside D (1) is a new triterpene glycoside, and compounds 2 and 3 are isolated from H. scabra for the first time. The glycosides 1-3 show the in vitro cytotoxicity against five human tumor cell lines in comparison to 10-hydroxycamptothecin." @default.
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- W199013206 date "2012-08-01" @default.
- W199013206 modified "2023-09-27" @default.
- W199013206 title "Triterpene Glycosides from Sea Cucumber Holothuria scabra with Cytotoxic Activity" @default.
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- W199013206 doi "https://doi.org/10.3969/j.issn.1674-6384.2012.03.002" @default.
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