Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990139192> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W1990139192 endingPage "680" @default.
- W1990139192 startingPage "671" @default.
- W1990139192 abstract "The time course of local cerebral radioactivity concentration after bolus inhalation of oxygen gas labeled with O-15 was measured in a rapid dynamic sequence of positron tomographic images. Four normal subjects were studied at rest. In each study, 15 multiple-slice image sets were acquired over a 3-min period in a Scanditronix model 384 tomograph. The radioactivity concentration in arterial blood was measured at 1-s intervals by means of a pump-fed flow-through detector. Pump effluent was directed to discrete samples that were separated into plasma and cell fractions to estimate the accumulation of labeled, recirculating water arising from systemic metabolism. Stereotactically matched scans of local cerebral blood flow and volume were acquired in the same imaging session, and the derived values were used as fixed parameters in the model fits of the time courses of pixel radioactivity in the oxygen study. Rapid nonlinear least-squares parameter optimization was used to estimate simultaneously the local CMRO2 and the brain/blood relative distribution volume for water in each image pixel. The same scan data were combined into effective single frames of various starting times and durations for analysis using the single-scan (autoradiographic) approach to CMRO2 estimation, which requires a presumed value for relative distribution volume. Oxygen use values derived using this approach were observed to be strongly dependent on the relative distribution volume value chosen, particularly for long study durations. However, for each gray matter region of interest studied, a uniform value for the relative distribution volume existed such that the estimated CMRO2 values were independent of the starting time and duration of the single scan used, and were furthermore the same as that yielded by the multiple-scan least-squares fitting of the total time course in the same region. We conclude that the properties of the single-scan and multiple-scan approaches are very similar at the same total study duration, provided that the value selected for the water relative distribution volume brings the measured and computed tissue time courses into correspondence." @default.
- W1990139192 created "2016-06-24" @default.
- W1990139192 creator A5008736543 @default.
- W1990139192 creator A5015602415 @default.
- W1990139192 creator A5066744035 @default.
- W1990139192 creator A5080263605 @default.
- W1990139192 creator A5084518880 @default.
- W1990139192 creator A5084644857 @default.
- W1990139192 date "1988-10-01" @default.
- W1990139192 modified "2023-09-24" @default.
- W1990139192 title "Direct Comparison of Single-Scan Autoradiographic with Multiple-Scan Least-Squares Fitting Approaches to PET CMRO<sub>2</sub> Estimation" @default.
- W1990139192 cites W2002618340 @default.
- W1990139192 cites W2011606453 @default.
- W1990139192 cites W2038782045 @default.
- W1990139192 cites W2044196442 @default.
- W1990139192 cites W2050112450 @default.
- W1990139192 cites W2057132504 @default.
- W1990139192 cites W2069429715 @default.
- W1990139192 cites W2079902872 @default.
- W1990139192 cites W2167534910 @default.
- W1990139192 cites W2168542458 @default.
- W1990139192 cites W2199359912 @default.
- W1990139192 doi "https://doi.org/10.1038/jcbfm.1988.114" @default.
- W1990139192 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3262115" @default.
- W1990139192 hasPublicationYear "1988" @default.
- W1990139192 type Work @default.
- W1990139192 sameAs 1990139192 @default.
- W1990139192 citedByCount "16" @default.
- W1990139192 countsByYear W19901391922015 @default.
- W1990139192 countsByYear W19901391922020 @default.
- W1990139192 countsByYear W19901391922022 @default.
- W1990139192 crossrefType "journal-article" @default.
- W1990139192 hasAuthorship W1990139192A5008736543 @default.
- W1990139192 hasAuthorship W1990139192A5015602415 @default.
- W1990139192 hasAuthorship W1990139192A5066744035 @default.
- W1990139192 hasAuthorship W1990139192A5080263605 @default.
- W1990139192 hasAuthorship W1990139192A5084518880 @default.
- W1990139192 hasAuthorship W1990139192A5084644857 @default.
- W1990139192 hasConcept C121332964 @default.
- W1990139192 hasConcept C126838900 @default.
- W1990139192 hasConcept C136229726 @default.
- W1990139192 hasConcept C147120987 @default.
- W1990139192 hasConcept C157767197 @default.
- W1990139192 hasConcept C158846371 @default.
- W1990139192 hasConcept C185592680 @default.
- W1990139192 hasConcept C192562407 @default.
- W1990139192 hasConcept C202100949 @default.
- W1990139192 hasConcept C2775842073 @default.
- W1990139192 hasConcept C2989005 @default.
- W1990139192 hasConcept C33923547 @default.
- W1990139192 hasConcept C42219234 @default.
- W1990139192 hasConcept C62520636 @default.
- W1990139192 hasConcept C71924100 @default.
- W1990139192 hasConceptScore W1990139192C121332964 @default.
- W1990139192 hasConceptScore W1990139192C126838900 @default.
- W1990139192 hasConceptScore W1990139192C136229726 @default.
- W1990139192 hasConceptScore W1990139192C147120987 @default.
- W1990139192 hasConceptScore W1990139192C157767197 @default.
- W1990139192 hasConceptScore W1990139192C158846371 @default.
- W1990139192 hasConceptScore W1990139192C185592680 @default.
- W1990139192 hasConceptScore W1990139192C192562407 @default.
- W1990139192 hasConceptScore W1990139192C202100949 @default.
- W1990139192 hasConceptScore W1990139192C2775842073 @default.
- W1990139192 hasConceptScore W1990139192C2989005 @default.
- W1990139192 hasConceptScore W1990139192C33923547 @default.
- W1990139192 hasConceptScore W1990139192C42219234 @default.
- W1990139192 hasConceptScore W1990139192C62520636 @default.
- W1990139192 hasConceptScore W1990139192C71924100 @default.
- W1990139192 hasIssue "5" @default.
- W1990139192 hasLocation W19901391921 @default.
- W1990139192 hasLocation W19901391922 @default.
- W1990139192 hasOpenAccess W1990139192 @default.
- W1990139192 hasPrimaryLocation W19901391921 @default.
- W1990139192 hasRelatedWork W2040536103 @default.
- W1990139192 hasRelatedWork W2053476696 @default.
- W1990139192 hasRelatedWork W2061304069 @default.
- W1990139192 hasRelatedWork W2080051139 @default.
- W1990139192 hasRelatedWork W2114450603 @default.
- W1990139192 hasRelatedWork W2120206316 @default.
- W1990139192 hasRelatedWork W2130856145 @default.
- W1990139192 hasRelatedWork W2155776456 @default.
- W1990139192 hasRelatedWork W2417317414 @default.
- W1990139192 hasRelatedWork W2953998806 @default.
- W1990139192 hasVolume "8" @default.
- W1990139192 isParatext "false" @default.
- W1990139192 isRetracted "false" @default.
- W1990139192 magId "1990139192" @default.
- W1990139192 workType "article" @default.