FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990139498> ?p ?o ?g. }

• W1990139498 endingPage "60" @default.
• W1990139498 startingPage "52" @default.
• W1990139498 abstract "We previously described that vasoactive intestinal peptide (VIP) increases synaptic transmission to hippocampal CA1 pyramidal cells at concentrations known to activate VIP-selective receptors (VPAC1 and VPAC2) but not the PACAP-selective PAC1 receptor. We now investigated the involvement of VPAC1 and VPAC2 receptors in the effects elicited by VIP as well as the transduction pathways activated by VIP to cause enhancement of synaptic transmission. Blockade of either VPAC1 or VPAC2 receptors with PG 97-269 (100 nM) or PG 99-465 (100 nM) inhibited VIP-induced enhancement of synaptic transmission. Selective activation of VPAC1 receptors with [K15, R16, L27] VIP(1-7)/GRF(8-27) (10 nM) or of VPAC2 receptors with RO 25-1553 (10 nM) increased synaptic transmission to CA1 pyramidal cells, and this increase was larger when both agonists were applied together. Inhibition of either PKA with H-89 (1 microM) or PKC with GF109203X (1 microM) attenuated the effect of VIP (1 nM). GF109203X (1 microM) abolished the effect of the VPAC1 agonist [K15, R16, L27] VIP(1-7)/GRF(8-27) (10 nM) on hippocampal synaptic transmission but that effect was not changed by H-89 (1 microM). The effect of RO 25-1553 (100 nM) obtained in the presence of both the PAC1 and VPAC1 antagonists, M65 (30 nM) and PG 97-269 (100 nM), was strongly inhibited by H-89 (1 microM) but not GF109203X (1 microM). It is concluded that VIP enhances synaptic transmission to CA1 pyramidal cell dendrites through VPAC1 and VPAC2 receptor activation. VPAC1-mediated actions are dependent on PKC activity, and VPAC2-mediated actions are responsible for the PKA-dependent actions of VIP on CA1 hippocampal transmission." @default.
• W1990139498 created "2016-06-24" @default.
• W1990139498 creator A5021255614 @default.
• W1990139498 creator A5031806410 @default.
• W1990139498 creator A5036701812 @default.
• W1990139498 date "2005-07-01" @default.
• W1990139498 modified "2023-10-05" @default.
• W1990139498 title "VIP enhances synaptic transmission to hippocampal CA1 pyramidal cells through activation of both VPAC1 and VPAC2 receptors" @default.
• W1990139498 cites W1481438484 @default.
• W1990139498 cites W1755902553 @default.
• W1990139498 cites W1977172474 @default.
• W1990139498 cites W1979470369 @default.
• W1990139498 cites W1979551618 @default.
• W1990139498 cites W1987123448 @default.
• W1990139498 cites W1989857487 @default.
• W1990139498 cites W1995616752 @default.
• W1990139498 cites W2012062796 @default.
• W1990139498 cites W2021613066 @default.
• W1990139498 cites W2029207096 @default.
• W1990139498 cites W2032763119 @default.
• W1990139498 cites W2033135454 @default.
• W1990139498 cites W2039365798 @default.
• W1990139498 cites W2045716874 @default.
• W1990139498 cites W2046868433 @default.
• W1990139498 cites W2053167415 @default.
• W1990139498 cites W2054628503 @default.
• W1990139498 cites W2063313379 @default.
• W1990139498 cites W2087711973 @default.
• W1990139498 cites W2090610674 @default.
• W1990139498 cites W2136422599 @default.
• W1990139498 cites W2148185781 @default.
• W1990139498 cites W2149837883 @default.
• W1990139498 cites W2168808956 @default.
• W1990139498 cites W2171988137 @default.
• W1990139498 cites W2231571999 @default.
• W1990139498 cites W4243246029 @default.
• W1990139498 doi "https://doi.org/10.1016/j.brainres.2005.04.077" @default.
• W1990139498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15935995" @default.
• W1990139498 hasPublicationYear "2005" @default.
• W1990139498 type Work @default.
• W1990139498 sameAs 1990139498 @default.
• W1990139498 citedByCount "28" @default.
• W1990139498 countsByYear W19901394982012 @default.
• W1990139498 countsByYear W19901394982013 @default.
• W1990139498 countsByYear W19901394982014 @default.
• W1990139498 countsByYear W19901394982015 @default.
• W1990139498 countsByYear W19901394982016 @default.
• W1990139498 countsByYear W19901394982017 @default.
• W1990139498 countsByYear W19901394982018 @default.
• W1990139498 countsByYear W19901394982020 @default.
• W1990139498 countsByYear W19901394982021 @default.
• W1990139498 countsByYear W19901394982022 @default.
• W1990139498 crossrefType "journal-article" @default.
• W1990139498 hasAuthorship W1990139498A5021255614 @default.
• W1990139498 hasAuthorship W1990139498A5031806410 @default.
• W1990139498 hasAuthorship W1990139498A5036701812 @default.
• W1990139498 hasConcept C118303440 @default.
• W1990139498 hasConcept C12554922 @default.
• W1990139498 hasConcept C126322002 @default.
• W1990139498 hasConcept C148762608 @default.
• W1990139498 hasConcept C169760540 @default.
• W1990139498 hasConcept C170493617 @default.
• W1990139498 hasConcept C185592680 @default.
• W1990139498 hasConcept C200170125 @default.
• W1990139498 hasConcept C2778938600 @default.
• W1990139498 hasConcept C55493867 @default.
• W1990139498 hasConcept C71924100 @default.
• W1990139498 hasConcept C8330315 @default.
• W1990139498 hasConcept C86803240 @default.
• W1990139498 hasConceptScore W1990139498C118303440 @default.
• W1990139498 hasConceptScore W1990139498C12554922 @default.
• W1990139498 hasConceptScore W1990139498C126322002 @default.
• W1990139498 hasConceptScore W1990139498C148762608 @default.
• W1990139498 hasConceptScore W1990139498C169760540 @default.
• W1990139498 hasConceptScore W1990139498C170493617 @default.
• W1990139498 hasConceptScore W1990139498C185592680 @default.
• W1990139498 hasConceptScore W1990139498C200170125 @default.
• W1990139498 hasConceptScore W1990139498C2778938600 @default.
• W1990139498 hasConceptScore W1990139498C55493867 @default.
• W1990139498 hasConceptScore W1990139498C71924100 @default.
• W1990139498 hasConceptScore W1990139498C8330315 @default.
• W1990139498 hasConceptScore W1990139498C86803240 @default.
• W1990139498 hasIssue "1" @default.
• W1990139498 hasLocation W19901394981 @default.
• W1990139498 hasLocation W19901394982 @default.
• W1990139498 hasOpenAccess W1990139498 @default.
• W1990139498 hasPrimaryLocation W19901394981 @default.
• W1990139498 hasRelatedWork W1985050767 @default.
• W1990139498 hasRelatedWork W1995616752 @default.
• W1990139498 hasRelatedWork W2000749144 @default.
• W1990139498 hasRelatedWork W2050492453 @default.
• W1990139498 hasRelatedWork W2053167415 @default.
• W1990139498 hasRelatedWork W2078476986 @default.
• W1990139498 hasRelatedWork W2610785804 @default.
• W1990139498 hasRelatedWork W3112069772 @default.
• W1990139498 hasRelatedWork W4213381725 @default.
• W1990139498 hasRelatedWork W4242931794 @default.
• W1990139498 hasVolume "1049" @default.

• next