FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990147750> ?p ?o ?g. }

• W1990147750 endingPage "916" @default.
• W1990147750 startingPage "909" @default.
• W1990147750 abstract "Abstract BACKGROUND Oct 3/4 (Octamer 3/4), a member of POU family has been considered as an important stem cell marker and essential transcription factor during human embryogenesis. In recent years, there have also been reports on presence of Oct 3/4 in differentiated benign and malignant human cells. The objective of this study was to investigate the transcription and the protein expression of Oct 3/4 isoforms in prostate cancer and benign prostate tissue. METHODS Thirty sex adenocarcinomas and eight cases of benign prostate hyperplasia were studied. The transcription of Oct 3/4 was analyzed using RT‐PCR approach associated with restriction digestion analysis. Oct 3/4 protein expression was studied by immunohistochemistry on paraffin sections using two different antibodies. RESULTS We identified only the transcript 2 of Oct 3/4 in prostate tumors and benign prostate hyperplasia. Immunohistochemistry verified these results, demonstrating only cytoplasmic localization of Oct 3/4. Transcription of type 1 of Oct 3/4 as well as protein expression with nuclear localization of Oct 3/4 isoform 1 were not detected. Oct 3/4 immunopositive tumors were also displayed neuroendocrine differentiation and showed androgen receptor immunopositivity. The stem cell markers CD44 and CD117 were not detected in Oct 3/4 immunopositive cells. CONCLUSION Our results indicate that only the cytoplasmic isoform 2 of Oct 3/4 is present in prostate cancer and benign prostate hyperplasia. The malignant and benign prostate cells, which are immunopositive for variant 2 of Oct 3/4, lack other stem cell markers supporting previously published data that variant 2 of Oct 3/4 is not a pluripotency marker. Prostate 69: 909–916, 2009. © 2009 Wiley‐Liss, Inc." @default.
• W1990147750 created "2016-06-24" @default.
• W1990147750 creator A5002009939 @default.
• W1990147750 creator A5002992871 @default.
• W1990147750 creator A5033896460 @default.
• W1990147750 creator A5050543270 @default.
• W1990147750 creator A5056003670 @default.
• W1990147750 date "2009-03-09" @default.
• W1990147750 modified "2023-10-16" @default.
• W1990147750 title "The expression of pluripotency marker Oct 3/4 in prostate cancer and benign prostate hyperplasia" @default.
• W1990147750 cites W1972383646 @default.
• W1990147750 cites W1978811387 @default.
• W1990147750 cites W1993253685 @default.
• W1990147750 cites W1997046409 @default.
• W1990147750 cites W2001413811 @default.
• W1990147750 cites W2003647591 @default.
• W1990147750 cites W2006991648 @default.
• W1990147750 cites W2014688699 @default.
• W1990147750 cites W2018187946 @default.
• W1990147750 cites W2037641339 @default.
• W1990147750 cites W2038526670 @default.
• W1990147750 cites W2039169692 @default.
• W1990147750 cites W2046812753 @default.
• W1990147750 cites W2064589748 @default.
• W1990147750 cites W2067206898 @default.
• W1990147750 cites W2071797171 @default.
• W1990147750 cites W2077623862 @default.
• W1990147750 cites W2087272148 @default.
• W1990147750 cites W2094454538 @default.
• W1990147750 cites W2126913564 @default.
• W1990147750 cites W2130736569 @default.
• W1990147750 cites W2142144785 @default.
• W1990147750 cites W2144108148 @default.
• W1990147750 cites W2147440133 @default.
• W1990147750 cites W2151258770 @default.
• W1990147750 cites W2163920802 @default.
• W1990147750 cites W2169900020 @default.
• W1990147750 doi "https://doi.org/10.1002/pros.20934" @default.
• W1990147750 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19274762" @default.
• W1990147750 hasPublicationYear "2009" @default.
• W1990147750 type Work @default.
• W1990147750 sameAs 1990147750 @default.
• W1990147750 citedByCount "25" @default.
• W1990147750 countsByYear W19901477502012 @default.
• W1990147750 countsByYear W19901477502013 @default.
• W1990147750 countsByYear W19901477502014 @default.
• W1990147750 countsByYear W19901477502015 @default.
• W1990147750 countsByYear W19901477502016 @default.
• W1990147750 countsByYear W19901477502018 @default.
• W1990147750 countsByYear W19901477502019 @default.
• W1990147750 countsByYear W19901477502021 @default.
• W1990147750 countsByYear W19901477502023 @default.
• W1990147750 crossrefType "journal-article" @default.
• W1990147750 hasAuthorship W1990147750A5002009939 @default.
• W1990147750 hasAuthorship W1990147750A5002992871 @default.
• W1990147750 hasAuthorship W1990147750A5033896460 @default.
• W1990147750 hasAuthorship W1990147750A5050543270 @default.
• W1990147750 hasAuthorship W1990147750A5056003670 @default.
• W1990147750 hasConcept C121608353 @default.
• W1990147750 hasConcept C126322002 @default.
• W1990147750 hasConcept C136302470 @default.
• W1990147750 hasConcept C142724271 @default.
• W1990147750 hasConcept C204232928 @default.
• W1990147750 hasConcept C2776235491 @default.
• W1990147750 hasConcept C2777562237 @default.
• W1990147750 hasConcept C2780192828 @default.
• W1990147750 hasConcept C28328180 @default.
• W1990147750 hasConcept C54355233 @default.
• W1990147750 hasConcept C71924100 @default.
• W1990147750 hasConcept C86803240 @default.
• W1990147750 hasConcept C87874733 @default.
• W1990147750 hasConceptScore W1990147750C121608353 @default.
• W1990147750 hasConceptScore W1990147750C126322002 @default.
• W1990147750 hasConceptScore W1990147750C136302470 @default.
• W1990147750 hasConceptScore W1990147750C142724271 @default.
• W1990147750 hasConceptScore W1990147750C204232928 @default.
• W1990147750 hasConceptScore W1990147750C2776235491 @default.
• W1990147750 hasConceptScore W1990147750C2777562237 @default.
• W1990147750 hasConceptScore W1990147750C2780192828 @default.
• W1990147750 hasConceptScore W1990147750C28328180 @default.
• W1990147750 hasConceptScore W1990147750C54355233 @default.
• W1990147750 hasConceptScore W1990147750C71924100 @default.
• W1990147750 hasConceptScore W1990147750C86803240 @default.
• W1990147750 hasConceptScore W1990147750C87874733 @default.
• W1990147750 hasIssue "9" @default.
• W1990147750 hasLocation W19901477501 @default.
• W1990147750 hasLocation W19901477502 @default.
• W1990147750 hasOpenAccess W1990147750 @default.
• W1990147750 hasPrimaryLocation W19901477501 @default.
• W1990147750 hasRelatedWork W2034398328 @default.
• W1990147750 hasRelatedWork W2350150832 @default.
• W1990147750 hasRelatedWork W2352355015 @default.
• W1990147750 hasRelatedWork W2378335291 @default.
• W1990147750 hasRelatedWork W2382341004 @default.
• W1990147750 hasRelatedWork W2386363070 @default.
• W1990147750 hasRelatedWork W2387713324 @default.
• W1990147750 hasRelatedWork W2439368546 @default.
• W1990147750 hasRelatedWork W2799343643 @default.

• next