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• W1990153313 abstract "A number of investigations have provided a growing body of evidence of the involvement of the γ-aminobutyric acid (GABA) transmitter system in the pathophysiology of schizophrenia and bipolar disorder. In this study, immunohistochemical and immunoblot techniques were employed in order to examine alterations of the GABAA receptor α1 and β2/3 subunits in the prefrontal cortex from postmortem subjects with schizophrenia and bipolar disorder. α1 immunoreactivity was observed in the neuropil of the prefrontal cortex and in the neuronal soma in specimens from both groups, as well as from normal controls. α1 immunolabeling in the neuronal soma from the schizophrenic group was more intense than that of the other two groups. The distribution of β2/3 immunoreactivity was similar to that of α1. β2/3 immunolabeling in the neuronal soma from the schizophrenia and bipolar disorder groups was more intense than that of the normal controls. The densitometry measurements, as well as the immunoblot analysis for α1 and β2/3 were highly consistent with the α1 and β2/3 immunohistochemistry results. The present study suggests that the expression of these two GABAA receptor subunits was altered in subjects with schizophrenia and bipolar disorder, but that the patterns of change differed between those with these two disorders." @default.
• W1990153313 created "2016-06-24" @default.
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• W1990153313 date "2004-09-01" @default.
• W1990153313 modified "2023-10-13" @default.
• W1990153313 title "Immunohistochemical and immunoblot study of GABAA α1 and β2/3 subunits in the prefrontal cortex of subjects with schizophrenia and bipolar disorder" @default.
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• W1990153313 doi "https://doi.org/10.1016/j.neures.2004.06.006" @default.
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