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- W1990154655 endingPage "1922" @default.
- W1990154655 startingPage "1911" @default.
- W1990154655 abstract "Negative selection is the process by which the developing lymphocyte receptor repertoire rids itself of autoreactive specificities. One mechanism of negative selection in developing T cells is the induction of apoptosis in immature CD4+CD8+ (DP) thymocytes, referred to as clonal deletion. Clonal deletion is necessarily T cell receptor (TCR) specific, but TCR signals alone are not lethal to purified DP thymocytes. Here, we identify two distinct mechanisms by which TCR-specific death of DP thymocytes can be induced. One mechanism requires simultaneous TCR and costimulatory signals initiated by CD28. The other mechanism is initiated by TCR signals in the absence of simultaneous costimulatory signals and is mediated by subsequent interaction with antigen-presenting cells. We propose that these mechanisms represent two distinct clonal deletion strategies that are differentially implemented during development depending on whether immature thymocytes encounter antigen in the thymic cortex or thymic medulla." @default.
- W1990154655 created "2016-06-24" @default.
- W1990154655 creator A5006278200 @default.
- W1990154655 creator A5019233921 @default.
- W1990154655 creator A5036066088 @default.
- W1990154655 creator A5048211558 @default.
- W1990154655 creator A5082082458 @default.
- W1990154655 date "1997-12-01" @default.
- W1990154655 modified "2023-10-17" @default.
- W1990154655 title "T Cell Receptor (TCR)-induced Death of Immature CD4+CD8+ Thymocytes by Two Distinct Mechanisms Differing in Their Requirement for CD28 Costimulation: Implications for Negative Selection in the Thymus" @default.
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- W1990154655 doi "https://doi.org/10.1084/jem.186.11.1911" @default.
- W1990154655 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2199155" @default.
- W1990154655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9382889" @default.
- W1990154655 hasPublicationYear "1997" @default.
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