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- W1990158757 abstract "Hepatitis B virus (HBV) infection is a major global health concern and is the most common cause of chronic liver disease worldwide. Despite the availability of a prophylactic vaccine, HBV infects around 400 million people worldwide, with endemic areas in Asia and Africa. HBV is an extremely infectious virus that is spread when infected blood, semen, or another body fluid enters the body of non-infected person and can also be spread from mother to infant at birth. Infection with HBV can be either acute or chronic; while adult infections have a relatively low rate of chronicity (around 5 %), neonatal infections usually have a high persistence rate. Chronic infection is usually asymptomatic for decades (except in rare fulminant), but HBV carriers are at risk of developing life-threatening cirrhosis and eventually hepatocellular carcinoma (HCC). Currently, more than 780,000 people die every year due to the (rare) acute or (more common) chronic consequences of hepatitis B. It is estimated that more than 240 million people have chronic (long-term) HBV liver infection (1.2 million in US). For many of these individuals, the current forms of therapy lack efficacy mainly because pathogenic mechanisms responsible for acute and chronic hepatitis B remain only partly clarified." @default.
- W1990158757 created "2016-06-24" @default.
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- W1990158757 date "2015-02-17" @default.
- W1990158757 modified "2023-09-23" @default.
- W1990158757 title "Bregs in Chronic HBV: Is It Time for Bragging Rights?" @default.
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- W1990158757 doi "https://doi.org/10.1007/s10620-015-3584-1" @default.
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