Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990162017> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W1990162017 endingPage "415" @default.
- W1990162017 startingPage "403" @default.
- W1990162017 abstract "Adenosine is one of the most important inhibitory modulators of heart function, producing negative inotropic, chronotropic and dromotropic effects and is also a major regulator of coronary circulation. The decrease in contractility by adenosine is mediated through inhibition of adenylyl cyclase by Gi-proteins coupled to adenosine receptors. However, little is known about the developmental differences in the effect of adenosine on cardiac cells. We have now shown that there is a striking developmental difference in the inhibitory effect of adenosine on isoproterenol-stimulated ICa between adult and newborn rabbit ventricular cells. Adenosine had no significant inhibitory effect on 0.1 muM isoproterenol-stimulated ICa in adult cells, while it completely blocked the 10 muM isoproterenol-stimulated ICa in newborn cells with an inhibitory potency similar to carbachol in newborn cells. Similarly, adenosine did not decrease the isoproterenol-stimulated cAMP levels in adult cells while it inhibited isoproterenol-stimulated cAMP levels significantly and equipotently to carbachol in newborn. However, for forskolin-stimulated ICa and cAMP levels in newborn cells, adenosine had a much lower inhibitory potency than carbachol. In adult cells, forskolin-stimulated ICa and cAMP levels were not affected by adenosine. We showed previously that the Gia3 isoform of inhibitory G protein was present in newborn cell membranes, but not detectable in adult cell membranes. We have now used a synthetic decapeptide corresponding to the C-terminal sequence of Gia3 in the patch pipette and have shown a selective partial block of the inhibitory action of adenosine for isoproterenol-stimulated ICa, suggesting that the inhibitory action of adenosine on ICa is mediated primarily through the Gia3 pathway." @default.
- W1990162017 created "2016-06-24" @default.
- W1990162017 creator A5046071928 @default.
- W1990162017 creator A5069291161 @default.
- W1990162017 creator A5083072147 @default.
- W1990162017 date "1996-02-01" @default.
- W1990162017 modified "2023-10-13" @default.
- W1990162017 title "Adenosine and Carbachol are not Equivalent in their Effects on?-type Calcium Current in Rabbit Ventricular Cells" @default.
- W1990162017 doi "https://doi.org/10.1006/jmcc.1996.0037" @default.
- W1990162017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8729071" @default.
- W1990162017 hasPublicationYear "1996" @default.
- W1990162017 type Work @default.
- W1990162017 sameAs 1990162017 @default.
- W1990162017 citedByCount "17" @default.
- W1990162017 countsByYear W19901620172015 @default.
- W1990162017 countsByYear W19901620172016 @default.
- W1990162017 countsByYear W19901620172017 @default.
- W1990162017 countsByYear W19901620172023 @default.
- W1990162017 crossrefType "journal-article" @default.
- W1990162017 hasAuthorship W1990162017A5046071928 @default.
- W1990162017 hasAuthorship W1990162017A5069291161 @default.
- W1990162017 hasAuthorship W1990162017A5083072147 @default.
- W1990162017 hasConcept C126322002 @default.
- W1990162017 hasConcept C134018914 @default.
- W1990162017 hasConcept C158328960 @default.
- W1990162017 hasConcept C170493617 @default.
- W1990162017 hasConcept C17077164 @default.
- W1990162017 hasConcept C185592680 @default.
- W1990162017 hasConcept C2776991684 @default.
- W1990162017 hasConcept C2777953023 @default.
- W1990162017 hasConcept C2778938600 @default.
- W1990162017 hasConcept C2778988552 @default.
- W1990162017 hasConcept C2779178603 @default.
- W1990162017 hasConcept C2779276759 @default.
- W1990162017 hasConcept C67907053 @default.
- W1990162017 hasConcept C71924100 @default.
- W1990162017 hasConcept C84393581 @default.
- W1990162017 hasConcept C86803240 @default.
- W1990162017 hasConceptScore W1990162017C126322002 @default.
- W1990162017 hasConceptScore W1990162017C134018914 @default.
- W1990162017 hasConceptScore W1990162017C158328960 @default.
- W1990162017 hasConceptScore W1990162017C170493617 @default.
- W1990162017 hasConceptScore W1990162017C17077164 @default.
- W1990162017 hasConceptScore W1990162017C185592680 @default.
- W1990162017 hasConceptScore W1990162017C2776991684 @default.
- W1990162017 hasConceptScore W1990162017C2777953023 @default.
- W1990162017 hasConceptScore W1990162017C2778938600 @default.
- W1990162017 hasConceptScore W1990162017C2778988552 @default.
- W1990162017 hasConceptScore W1990162017C2779178603 @default.
- W1990162017 hasConceptScore W1990162017C2779276759 @default.
- W1990162017 hasConceptScore W1990162017C67907053 @default.
- W1990162017 hasConceptScore W1990162017C71924100 @default.
- W1990162017 hasConceptScore W1990162017C84393581 @default.
- W1990162017 hasConceptScore W1990162017C86803240 @default.
- W1990162017 hasIssue "2" @default.
- W1990162017 hasLocation W19901620171 @default.
- W1990162017 hasLocation W19901620172 @default.
- W1990162017 hasOpenAccess W1990162017 @default.
- W1990162017 hasPrimaryLocation W19901620171 @default.
- W1990162017 hasRelatedWork W1934495609 @default.
- W1990162017 hasRelatedWork W1977982331 @default.
- W1990162017 hasRelatedWork W1980806930 @default.
- W1990162017 hasRelatedWork W1984957160 @default.
- W1990162017 hasRelatedWork W2007813873 @default.
- W1990162017 hasRelatedWork W2019451990 @default.
- W1990162017 hasRelatedWork W2028910572 @default.
- W1990162017 hasRelatedWork W2043628569 @default.
- W1990162017 hasRelatedWork W2087754009 @default.
- W1990162017 hasRelatedWork W2150623384 @default.
- W1990162017 hasVolume "28" @default.
- W1990162017 isParatext "false" @default.
- W1990162017 isRetracted "false" @default.
- W1990162017 magId "1990162017" @default.
- W1990162017 workType "article" @default.