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• W1990167660 abstract "Oxidized alginate (ADA) and oxidized alginate blended with chitosan (ADA-Chit) were prepared in the presence of borax and CaCl2, and their interactions with an antifolate drug, pyrimethamine (PYR), have been investigated. Tablets with a mean diameter of 1.2 ± 0.06 cm were produced and drug interactions were performed in dimethyl sulfoxide (DMSO) using isothermal titration calorimetry (ITC). From ITC responses, the enthalpy changes of interaction PYR/materials, ΔintH, have been determined and were found to be −11.73 ± 0.517 kJ mol−1 for ADA and −4.86 ± 0.156 kJ mol−1 for ADA-Chit. The PYR encapsulation of approximately 75% was achieved for both materials, as measured by UV spectrometer." @default.
• W1990167660 created "2016-06-24" @default.
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• W1990167660 date "2008-03-18" @default.
• W1990167660 modified "2023-10-16" @default.
• W1990167660 title "Polysaccharide-Based Hydrogels: Preparation, Characterization, and Drug Interaction Behaviour" @default.
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• W1990167660 doi "https://doi.org/10.1021/bm7011983" @default.
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