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- W1990168204 endingPage "626" @default.
- W1990168204 startingPage "613" @default.
- W1990168204 abstract "Many studies demonstrate that exposure to testicular steroids such as testosterone early in life masculinizes the developing brain, leading to permanent changes in behavior. Traditionally, masculinization of the rodent brain is believed to depend on estrogen receptors (ERs) and not androgen receptors (ARs). According to the aromatization hypothesis, circulating testosterone from the testes is converted locally in the brain by aromatase to estrogens, which then activate ERs to masculinize the brain. However, an emerging body of evidence indicates that the aromatization hypothesis cannot fully account for sex differences in brain morphology and behavior, and that androgens acting on ARs also play a role. The testicular feminization mutation (Tfm) in rodents, which produces a nonfunctional AR protein, provides an excellent model to probe the role of ARs in the development of brain and behavior. Tfm rodent models indicate that ARs are normally involved in the masculinization of many sexually dimorphic brain regions and a variety of behaviors, including sexual behaviors, stress response and cognitive processing. We review the role of ARs in the development of the brain and behavior, with an emphasis on what has been learned from Tfm rodents as well as from related mutations in humans causing complete androgen insensitivity." @default.
- W1990168204 created "2016-06-24" @default.
- W1990168204 creator A5011976319 @default.
- W1990168204 creator A5041531416 @default.
- W1990168204 creator A5064546194 @default.
- W1990168204 creator A5079701180 @default.
- W1990168204 date "2008-05-01" @default.
- W1990168204 modified "2023-09-30" @default.
- W1990168204 title "The role of androgen receptors in the masculinization of brain and behavior: What we've learned from the testicular feminization mutation" @default.
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