Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990172277> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W1990172277 endingPage "508" @default.
- W1990172277 startingPage "500" @default.
- W1990172277 abstract "Intracellular [Ca2+]i handling has been shown to be altered in isolated ventricular myocytes from patients with terminal heart failure. The aim of this study was to evaluate if alterations of intracellular [Ca2+]i handling and triggering Ca2+ currents in cardiomyopathic hamsters (strain BIO 14.6) with congestive heart failure might be similar to changes found in myocytes of patients with terminal heart failure and, therefore if the hamster might serve as a model for heart failure in man. Cells were isolated from hearts of hamsters developing hereditary cardiomyopathy (CMP) (strain BIO 14.6) at 12-14 months of age with overt signs of congestive heart failure. Results were compared with age-matched, undiseased control animals (CTRL). [Ca2+]i transients and Ca2+ currents were recorded simultaneously from isolated cells under voltage clamp perfused internally with the Ca2+ indicator, Fura-2. Ca2+ current densities in myocytes from CMP hamsters were -6.6 +/- 0.6 versus -8.3 +/- 0.5 microA/cm2 (P < 0.05) in CTRL. Resting [Ca2+]i levels were not significantly different. Peak [Ca2+]i transients were significantly decreased in CMP cells (450 +/- 52 nM versus 1031 +/- 98 nM in CTRL, P < 0.05). The rate of diastolic [Ca2+]i decay was slower in cells from CMP animals (t1/2: 167 +/- 19 versus 109 +/- 16 ms; P < 0.05). A moderate negative correlation was found between cell surface area and [Ca2+]i transients (r = 0.42; P < 0.05). It is concluded that changes of intracellular [Ca2+]i handling may play an important role in altered contractility of the myocardium of hamsters with hereditary cardiomyopathy in the late stage of congestive heart failure.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W1990172277 created "2016-06-24" @default.
- W1990172277 creator A5028685517 @default.
- W1990172277 creator A5030440436 @default.
- W1990172277 creator A5077493598 @default.
- W1990172277 creator A5084628427 @default.
- W1990172277 date "1994-12-01" @default.
- W1990172277 modified "2023-09-26" @default.
- W1990172277 title "Intracellular calcium handling in isolated ventricular myocytes from cardiomyopathic hamsters (strain BIO 14.6) with congestive heart failure" @default.
- W1990172277 cites W1982520540 @default.
- W1990172277 cites W1982871296 @default.
- W1990172277 cites W1997813669 @default.
- W1990172277 cites W2009667219 @default.
- W1990172277 cites W2011124901 @default.
- W1990172277 cites W2023482296 @default.
- W1990172277 cites W2065844888 @default.
- W1990172277 cites W2080673378 @default.
- W1990172277 cites W2081406984 @default.
- W1990172277 cites W2082187526 @default.
- W1990172277 cites W2083000679 @default.
- W1990172277 cites W2084453154 @default.
- W1990172277 cites W2120337309 @default.
- W1990172277 cites W2141260882 @default.
- W1990172277 cites W2150194114 @default.
- W1990172277 cites W2151615819 @default.
- W1990172277 cites W2166169771 @default.
- W1990172277 cites W2292663852 @default.
- W1990172277 cites W2422845570 @default.
- W1990172277 cites W3146777902 @default.
- W1990172277 cites W4376849603 @default.
- W1990172277 doi "https://doi.org/10.1016/0143-4160(94)90080-9" @default.
- W1990172277 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7712543" @default.
- W1990172277 hasPublicationYear "1994" @default.
- W1990172277 type Work @default.
- W1990172277 sameAs 1990172277 @default.
- W1990172277 citedByCount "25" @default.
- W1990172277 countsByYear W19901722772016 @default.
- W1990172277 crossrefType "journal-article" @default.
- W1990172277 hasAuthorship W1990172277A5028685517 @default.
- W1990172277 hasAuthorship W1990172277A5030440436 @default.
- W1990172277 hasAuthorship W1990172277A5077493598 @default.
- W1990172277 hasAuthorship W1990172277A5084628427 @default.
- W1990172277 hasConcept C126322002 @default.
- W1990172277 hasConcept C134018914 @default.
- W1990172277 hasConcept C164705383 @default.
- W1990172277 hasConcept C181080969 @default.
- W1990172277 hasConcept C185592680 @default.
- W1990172277 hasConcept C207200792 @default.
- W1990172277 hasConcept C2778198053 @default.
- W1990172277 hasConcept C2778575167 @default.
- W1990172277 hasConcept C2778797674 @default.
- W1990172277 hasConcept C519063684 @default.
- W1990172277 hasConcept C55493867 @default.
- W1990172277 hasConcept C57900726 @default.
- W1990172277 hasConcept C71924100 @default.
- W1990172277 hasConcept C79879829 @default.
- W1990172277 hasConcept C84393581 @default.
- W1990172277 hasConceptScore W1990172277C126322002 @default.
- W1990172277 hasConceptScore W1990172277C134018914 @default.
- W1990172277 hasConceptScore W1990172277C164705383 @default.
- W1990172277 hasConceptScore W1990172277C181080969 @default.
- W1990172277 hasConceptScore W1990172277C185592680 @default.
- W1990172277 hasConceptScore W1990172277C207200792 @default.
- W1990172277 hasConceptScore W1990172277C2778198053 @default.
- W1990172277 hasConceptScore W1990172277C2778575167 @default.
- W1990172277 hasConceptScore W1990172277C2778797674 @default.
- W1990172277 hasConceptScore W1990172277C519063684 @default.
- W1990172277 hasConceptScore W1990172277C55493867 @default.
- W1990172277 hasConceptScore W1990172277C57900726 @default.
- W1990172277 hasConceptScore W1990172277C71924100 @default.
- W1990172277 hasConceptScore W1990172277C79879829 @default.
- W1990172277 hasConceptScore W1990172277C84393581 @default.
- W1990172277 hasIssue "6" @default.
- W1990172277 hasLocation W19901722771 @default.
- W1990172277 hasLocation W19901722772 @default.
- W1990172277 hasOpenAccess W1990172277 @default.
- W1990172277 hasPrimaryLocation W19901722771 @default.
- W1990172277 hasRelatedWork W1990172277 @default.
- W1990172277 hasRelatedWork W2003842308 @default.
- W1990172277 hasRelatedWork W2037126054 @default.
- W1990172277 hasRelatedWork W2064236298 @default.
- W1990172277 hasRelatedWork W2095093072 @default.
- W1990172277 hasRelatedWork W2130994917 @default.
- W1990172277 hasRelatedWork W2384457103 @default.
- W1990172277 hasRelatedWork W2415237756 @default.
- W1990172277 hasRelatedWork W2748952813 @default.
- W1990172277 hasRelatedWork W4250600277 @default.
- W1990172277 hasVolume "16" @default.
- W1990172277 isParatext "false" @default.
- W1990172277 isRetracted "false" @default.
- W1990172277 magId "1990172277" @default.
- W1990172277 workType "article" @default.