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• W1990176825 abstract "The nuclear phosphoprotein p53 is frequently inactivated in human cancer. Although it was previously classified as an oncoprotein, p53 has emerged as a tumor suppressor controlling cell cycle progression by regulating gene transcription. A major biochemical property of wild-type p53 is its ability to bind DNA in a sequence-specific manner. The human c-H-ras gene contains within its first intron sequences that partially match the p53 consensus binding site. We determined that these sequences represent a bona fide p53 element, since in vitro translated wild-type p53 recognized them with high affinity. Furthermore, wild-type p53 activated transcription from a reporter plasmid containing the c-H-ras element as an enhancer. These findings suggest that p53 regulates cellular growth by coordinate transcription of genes that suppress and promote cellular proliferation." @default.
• W1990176825 created "2016-06-24" @default.
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• W1990176825 date "1995-11-01" @default.
• W1990176825 modified "2023-09-24" @default.
• W1990176825 title "SPECIFIC RECOGNITION OF A TRANSCRIPTIONAL ELEMENT WITHIN THE HUMAN H-RAS PROTOONCOGENE BY THE P53 TUMOR-SUPPRESSOR" @default.
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• W1990176825 doi "https://doi.org/10.3892/ijo.7.5.1029" @default.
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