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- W1990180168 abstract "Newborn inhibitory neurons migrate into existing neural circuitry in the olfactory bulb throughout the lifetime of adult mammals. While many factors contribute to the maturation of neural circuits, intracellular calcium is believed to play an important role in regulating cell migration and the development of neural systems. However, the factors underlying calcium signaling within newborn neurons in the postnatal olfactory bulb are not well understood. Here, we show that migrating, immature neurons in the olfactory bulb subependymal layer (SEL) undergo spontaneous and depolarization-evoked intracellular calcium transients mediated by high-voltage-activated L-type calcium channels. In contrast to migrating immature neurons in other brain regions, modulation of calcium transients in SEL cells does not alter their rate of migration." @default.
- W1990180168 created "2016-06-24" @default.
- W1990180168 creator A5026877245 @default.
- W1990180168 creator A5062540407 @default.
- W1990180168 date "2009-02-25" @default.
- W1990180168 modified "2023-10-15" @default.
- W1990180168 title "L-Type Calcium Channels Govern Calcium Signaling in Migrating Newborn Neurons in the Postnatal Olfactory Bulb" @default.
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- W1990180168 doi "https://doi.org/10.1523/jneurosci.5333-08.2009" @default.
- W1990180168 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2677619" @default.
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