FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990183146> ?p ?o ?g. }

• W1990183146 endingPage "2" @default.
• W1990183146 startingPage "1" @default.
• W1990183146 abstract "Recent discovery of induced pluripotent stem cells (iPSCs) open the great possibility to use patient own tissue to the previously incurable diseases. Multipotent adult stem/progenitor cells have been identified in nearly all human organs. These cells are expanded in vitro and are possible to be used for personalized cell therapy. This special issue collected the articles which discussed recent progresses in this field. Our body has self-defense systems to recover from damages. However, once tissues are damaged extensively, damaged tissues cannot be recovered. These include hepatic (C. H. Chiang, M. A. Puglisi), kidney, lung, and heart failures. Also in neurodegenerative diseases including Parkinson's disease, Alzheimer diseases, and ALS, patient cells are difficult to recover (H. Y. Ha). External stimuli such as high dose of irradiation caused by cancer treatment (B. Phulpin) will induce irreversible damages. There exist genetic disorders for which there is no cure including progressive muscular dystrophies (E. Zucconi), cystic fibrosis (V. Paracchini). Further age-related dysfunctions are difficult to be recovered. One example is articular cartilage (S. Seo). Currently transplantation has been shown to be an effective treatment for these tissue failures. However, transplantation has serious problems: shortage of organs to be transplanted and immune rejection caused by great heterogeneity of human HLA. Recent progresses of biotechnology open a new hope to treat incurable diseases by using patient own tissues. This special issue aimed to gather scientific papers about recent progresses in this field.iPSCs are novel stem cell populations induced from mouse and human adult somatic cells through reprogramming by transduction of defined transcription factors. These cells open the great possibility to personalized cell therapy to treat incurable diseases (K. Seiler, T. Kunkanjanawan, H. Y. Ha). Compared to ES cells, iPSCs are not rejected by host immune cells theoretically. At least iPS cells are not rejected once these cells are differentiated (C. H. Chiang).Mesenchymal stromal cells (MSCs) from various sources including bone marrow (S. W. Gendebien), adipose tissue (W. Lattanzi), dental pulp, placenta, umbilical cord (E. Zucconi, S. Park), menstrual blood (M. C. Rodrigues) and amniotic mesenchymal stromal cells (V. Paracchini) have been studied extensively by animal models.Tissue stem cells are also used for personalized stem cell therapy. Muscle-derived stem cells for bone formation (X. Li), blood vessel-derived stem cells regenerate myofibers in injured and dystrophic skeletal muscles as well as improve cardiac function after myocardial infarction (C. W. Chen). Olfactory ensheathing cells (OECs) into nerve or spinal cord injuries can promote axonal regeneration and remyelination and restore functional recovery (C. Radtke). Some stem-like cells reside in the transition area between the peripheral corneal endothelium (CE) and the anterior nonfiltering portion of the trabecular meshwork (TM) replacing the lost CE (W. Y. Yu).Cell culture on scaffold enhances cell growth and differentiation. Hydroxyapatite (HA) coating of (PCL/PVA) nanofibers enhances bone repair (E. Prosecka).There are a number of reports for limitations of current technologies that hinder iPSCs into practical use. Immunogenicity to syngeneic mice and tumor formation are reported. MSCs also might promote tumor growth. MSCs immunomodulatory properties affect greatly the host. More works are sure to be needed to overcome these problems." @default.
• W1990183146 created "2016-06-24" @default.
• W1990183146 creator A5013328356 @default.
• W1990183146 creator A5049050220 @default.
• W1990183146 creator A5079962049 @default.
• W1990183146 date "2012-01-01" @default.
• W1990183146 modified "2023-09-29" @default.
• W1990183146 title "Toward Personalized Cell Therapies by Using Stem Cells" @default.
• W1990183146 cites W100674867 @default.
• W1990183146 cites W110166956 @default.
• W1990183146 cites W120380984 @default.
• W1990183146 cites W1244702794 @default.
• W1990183146 cites W145965257 @default.
• W1990183146 cites W1487781413 @default.
• W1990183146 cites W1499440534 @default.
• W1990183146 cites W150358514 @default.
• W1990183146 cites W1507999061 @default.
• W1990183146 cites W1518489992 @default.
• W1990183146 cites W1524165547 @default.
• W1990183146 cites W1524314405 @default.
• W1990183146 cites W1534334436 @default.
• W1990183146 cites W1536989454 @default.
• W1990183146 cites W1537104679 @default.
• W1990183146 cites W1569377661 @default.
• W1990183146 cites W1582425028 @default.
• W1990183146 cites W1589895816 @default.
• W1990183146 cites W1592304046 @default.
• W1990183146 cites W1596569815 @default.
• W1990183146 cites W1608107506 @default.
• W1990183146 cites W171564825 @default.
• W1990183146 cites W1745204207 @default.
• W1990183146 cites W1750906271 @default.
• W1990183146 cites W1800265185 @default.
• W1990183146 cites W1866157615 @default.
• W1990183146 cites W1873195168 @default.
• W1990183146 cites W1876428604 @default.
• W1990183146 cites W1889052541 @default.
• W1990183146 cites W1900762885 @default.
• W1990183146 cites W1906903025 @default.
• W1990183146 cites W1909729402 @default.
• W1990183146 cites W1912510903 @default.
• W1990183146 cites W1925667723 @default.
• W1990183146 cites W1938282147 @default.
• W1990183146 cites W1938812606 @default.
• W1990183146 cites W1944220258 @default.
• W1990183146 cites W1948275303 @default.
• W1990183146 cites W1949342287 @default.
• W1990183146 cites W1949943515 @default.
• W1990183146 cites W1949954354 @default.
• W1990183146 cites W1952564517 @default.
• W1990183146 cites W1962351050 @default.
• W1990183146 cites W1964720896 @default.
• W1990183146 cites W1964812077 @default.
• W1990183146 cites W1965690091 @default.
• W1990183146 cites W1966458146 @default.
• W1990183146 cites W1966672254 @default.
• W1990183146 cites W1966786218 @default.
• W1990183146 cites W1966934424 @default.
• W1990183146 cites W1966954211 @default.
• W1990183146 cites W1967101823 @default.
• W1990183146 cites W1967111534 @default.
• W1990183146 cites W1967464880 @default.
• W1990183146 cites W1968255500 @default.
• W1990183146 cites W1968996211 @default.
• W1990183146 cites W1969333904 @default.
• W1990183146 cites W1970007383 @default.
• W1990183146 cites W1970177659 @default.
• W1990183146 cites W1970209262 @default.
• W1990183146 cites W1970831691 @default.
• W1990183146 cites W1972158911 @default.
• W1990183146 cites W1972334415 @default.
• W1990183146 cites W1972774352 @default.
• W1990183146 cites W1973466789 @default.
• W1990183146 cites W1973485468 @default.
• W1990183146 cites W1973640772 @default.
• W1990183146 cites W1973651655 @default.
• W1990183146 cites W1973880590 @default.
• W1990183146 cites W1973911154 @default.
• W1990183146 cites W1974047788 @default.
• W1990183146 cites W1974323483 @default.
• W1990183146 cites W1974652594 @default.
• W1990183146 cites W1975724680 @default.
• W1990183146 cites W1975807306 @default.
• W1990183146 cites W1975807748 @default.
• W1990183146 cites W1976628761 @default.
• W1990183146 cites W1976968085 @default.
• W1990183146 cites W1978173381 @default.
• W1990183146 cites W1978370369 @default.
• W1990183146 cites W1978371504 @default.
• W1990183146 cites W1978560791 @default.
• W1990183146 cites W1978702852 @default.
• W1990183146 cites W1979043688 @default.
• W1990183146 cites W1979707617 @default.
• W1990183146 cites W1980772641 @default.
• W1990183146 cites W1981601043 @default.
• W1990183146 cites W1981621010 @default.
• W1990183146 cites W1982022033 @default.
• W1990183146 cites W1982946759 @default.

• next