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- W1990202439 abstract "Two chiral pyridinylmethyl diphenylprolinolsilyl ether derivatives have been synthesized from N-alkylation of (S)-diphenylprolinolsilyl ether in a single step. They were successfully applied as ligands in the Cu(II)-catalyzed enantioselective Henry reaction between aldehydes and nitromethane in ethanol at room temperature. A variety of chiral Henry products β-nitroalcohols were obtained in good to high yields (up to 94%) with high to excellent enantioselectivities (up to 94% ee) under the optimized reaction conditions. The results indicate that the bulky substituent diphenylprolinolsilyl ether of ligand 2 plays an important role to induce the high stereoselectivity of the process." @default.
- W1990202439 created "2016-06-24" @default.
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- W1990202439 date "2013-02-01" @default.
- W1990202439 modified "2023-10-08" @default.
- W1990202439 title "Highly asymmetric Henry reaction catalyzed by chiral copper(II) complexes" @default.
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- W1990202439 doi "https://doi.org/10.1016/j.tetlet.2012.11.053" @default.
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