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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990203464> ?p ?o ?g. }

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• W1990203464 abstract "Furan is a liver carcinogen and toxicant. Furan is oxidized to the reactive dialdehyde, cis-2-butene-1,4-dial, by microsomal enzymes. This reactive metabolite readily reacts with glutathione nonenzymatically to form conjugates. A high-performance liquid chromatography-electrochemical method for the detection of cis-2-butene-1,4-dial-glutathione (GSH) conjugates in microsomal preparations was developed to measure the extent of furan metabolism to cis-2-butene-1,4-dial in vitro. Previously unobserved mono-GSH reaction products of cis-2-butene-1,4-dial were detected in addition to the already characterized bis-GSH conjugates. Chemical characterization of these compounds indicated that the alpha-amino group of glutathione had reacted with cis-2-butene-1,4-dial to form a thiol-substituted pyrrole adduct. The analytical method was used to estimate the extent of furan oxidation in rat liver microsomes from untreated or acetone-pretreated F344 rats as well as in human P450 2E1 Supersomes. Our results confirm that cytochrome P450 2E1 can catalyze the oxidation of furan to cis-2-butene-1,4-dial. However, the data are also consistent with the involvement of other P450 enzymes in the oxidation of furan in untreated animals. This assay will be a valuable tool to explore tissue and species differences in rates of furan oxidation." @default.
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• W1990203464 date "2005-07-08" @default.
• W1990203464 modified "2023-09-28" @default.
• W1990203464 title "GLUTATHIONE TRAPPING TO MEASURE MICROSOMAL OXIDATION OF FURAN TO<i>CIS</i>-2-BUTENE-1,4-DIAL" @default.
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• W1990203464 doi "https://doi.org/10.1124/dmd.105.004432" @default.
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