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• W1990205250 abstract "Abstract Isolated perfused rat liver preparations were utilized to study the drug-induced modification of biliary excretion of [ 14 C]4-chlorobiphenyl (1-CB) and [ 14 C]2,4,5-2′,4′,5′-hexachlorobiphenyl (6-CB) and their metabolites. The effect of pretreatment of rats with mirex was compared with that of phenobarbital (PB) and 6-CB by measuring the biliary excretion of 1-CB and the pharmacokinetics of 1-CB and its metabolites in the perfusate of liver preparations obtained from control and treated rats. The biliary excretion of 1-CB metabolites by mirex-pretreated livers was suppressed by 92% of that in control livers. The rate of metabolism of 1-CB by mirexpretreated livers was slightly decreased. However, the suppression of biliary excretion of 1-CB metabolites does not appear to be related either to decreased rate of metabolism or to the rate of bile flow. These conclusions are borne out from the following two observations: first, the metabolites of 1-CB accumulate at increasing concentrations in the perfusate of mirexpretreated livers; secondly, mirex-pretreated livers had elevated bile flows. Biliary excretion of exogenously added metabolites of 1-CB by mirextreated livers was suppressed by 85% of that of control livers. PB and 6-CB pretreatment caused a statistically significant increase in the biliary excretion of 1-CB metabolites. This was accompanied by a slight but statistically nonsignificant increase in the rate of bile flow. Biliary excretion of 6-CB was completely suppressed by mirex pretreatment and was unaffected by PB. These results indicate that while PB-induced modification of biliary excretion of PCBs may be associated with their metabolism, mirex-induced suppression is associated with the transport of otherwise readily excretable metabolites from the hepatocytes into the bile canaliculi." @default.
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• W1990205250 date "1976-05-01" @default.
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• W1990205250 title "Mirex-induced suppression of biliary excretion of polychlorinated biphenyl compounds" @default.
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• W1990205250 doi "https://doi.org/10.1016/0041-008x(76)90015-6" @default.
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