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- W1990223878 abstract "Anthrax is a zoonotic infection caused by the gram-positive, aerobic, spore-forming bacterium Bacillus anthracis. Depending on the origin of the infection, serious health problems or mortality is possible. The virulence of B. anthracis is reliant on three pathogenic factors, which are secreted upon infection: protective antigen (PA), lethal factor (LF), and edema factor (EF). Systemic illness results from LF and EF entering cells through the formation of a complex with the heptameric form of PA, bound to the membrane of infected cells through its receptor. The currently available anthrax vaccines have multiple drawbacks, and recombinant PA is considered a promising second-generation vaccine candidate. However, the inherent chemical instability of PA through Asn deamidation at multiple sites prevents its use after long-term storage owing to loss of potency. Moreover, there is a distinct possibility of B. anthracis being used as a bioweapon; thus, the developed vaccine should remain efficacious and stable over the long-term. Second-generation anthrax vaccines with appropriate adjuvant formulations for enhanced immunogenicity and safety are desired. In this article, using protein engineering approaches, we have reviewed the stabilization of anthrax vaccine candidates that are currently licensed or under preclinical and clinical trials. We have also proposed a formulation to enhance recombinant PA vaccine potency via adjuvant formulation." @default.
- W1990223878 created "2016-06-24" @default.
- W1990223878 creator A5002047876 @default.
- W1990223878 date "2000-08-01" @default.
- W1990223878 modified "2023-10-13" @default.
- W1990223878 title "Immunological concepts of vaccine adjuvant activity" @default.
- W1990223878 cites W1483162601 @default.
- W1990223878 cites W1485224098 @default.
- W1990223878 cites W1511634277 @default.
- W1990223878 cites W1543460784 @default.
- W1990223878 cites W1602277155 @default.
- W1990223878 cites W1604006332 @default.
- W1990223878 cites W1637232318 @default.
- W1990223878 cites W1660413876 @default.
- W1990223878 cites W1661544713 @default.
- W1990223878 cites W1723158139 @default.
- W1990223878 cites W1963895695 @default.
- W1990223878 cites W1968134126 @default.
- W1990223878 cites W1974210099 @default.
- W1990223878 cites W1976046966 @default.
- W1990223878 cites W1977007393 @default.
- W1990223878 cites W1977298268 @default.
- W1990223878 cites W1977437107 @default.
- W1990223878 cites W1977527332 @default.
- W1990223878 cites W1978416272 @default.
- W1990223878 cites W1979132095 @default.
- W1990223878 cites W1983695293 @default.
- W1990223878 cites W1984421836 @default.
- W1990223878 cites W1989527030 @default.
- W1990223878 cites W1990156671 @default.
- W1990223878 cites W1991464867 @default.
- W1990223878 cites W1991804259 @default.
- W1990223878 cites W1994263397 @default.
- W1990223878 cites W1994601252 @default.
- W1990223878 cites W1994902503 @default.
- W1990223878 cites W2002861511 @default.
- W1990223878 cites W2003444408 @default.
- W1990223878 cites W2005788144 @default.
- W1990223878 cites W2006025841 @default.
- W1990223878 cites W2009238488 @default.
- W1990223878 cites W2009509313 @default.
- W1990223878 cites W2011424311 @default.
- W1990223878 cites W2016101919 @default.
- W1990223878 cites W2018590888 @default.
- W1990223878 cites W2031745415 @default.
- W1990223878 cites W2033521127 @default.
- W1990223878 cites W2035572849 @default.
- W1990223878 cites W2035580952 @default.
- W1990223878 cites W2042626190 @default.
- W1990223878 cites W2043529027 @default.
- W1990223878 cites W2046975596 @default.
- W1990223878 cites W2048033632 @default.
- W1990223878 cites W2055861239 @default.
- W1990223878 cites W2057018521 @default.
- W1990223878 cites W2058881251 @default.
- W1990223878 cites W2067464003 @default.
- W1990223878 cites W2071415293 @default.
- W1990223878 cites W2071482126 @default.
- W1990223878 cites W2071813191 @default.
- W1990223878 cites W2075453847 @default.
- W1990223878 cites W2081145861 @default.
- W1990223878 cites W2085712060 @default.
- W1990223878 cites W2088823703 @default.
- W1990223878 cites W2090481553 @default.
- W1990223878 cites W2090854702 @default.
- W1990223878 cites W2091140484 @default.
- W1990223878 cites W2091613002 @default.
- W1990223878 cites W2093284893 @default.
- W1990223878 cites W2102857621 @default.
- W1990223878 cites W2105382508 @default.
- W1990223878 cites W2109865134 @default.
- W1990223878 cites W2110893447 @default.
- W1990223878 cites W2112249032 @default.
- W1990223878 cites W2114737175 @default.
- W1990223878 cites W2123076394 @default.
- W1990223878 cites W2132552157 @default.
- W1990223878 cites W2133947244 @default.
- W1990223878 cites W2134934993 @default.
- W1990223878 cites W2137182923 @default.
- W1990223878 cites W2137268127 @default.
- W1990223878 cites W2158500407 @default.
- W1990223878 cites W2171345725 @default.
- W1990223878 cites W2182386412 @default.
- W1990223878 cites W2300652355 @default.
- W1990223878 cites W2332423443 @default.
- W1990223878 cites W2334981078 @default.
- W1990223878 cites W4238917507 @default.
- W1990223878 cites W4313344599 @default.
- W1990223878 doi "https://doi.org/10.1016/s0952-7915(00)00120-5" @default.
- W1990223878 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10899018" @default.
- W1990223878 hasPublicationYear "2000" @default.
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