FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990230662> ?p ?o ?g. }

• W1990230662 endingPage "58" @default.
• W1990230662 startingPage "51" @default.
• W1990230662 abstract "The mechanism by which ouabain causes excitation of canine colonic circular smooth muscle was investigated. Ouabain-induced depolarization and increase in contractility were related to the concentration of extracellular sodium and prevented by complete substitution of sodium ions with N-methyl-D-glucamine or lithium ions. Absence of external sodium ions did not prevent the depolarization and increase in contractility induced by tetraethylammonium. Exposure of the muscle strips to sodium-free solutions produced a transient hyperpolarization and decrease in the input membrane resistance consistent with the hypothesis that intracellular sodium blocks potassium conductance. The relationship between the membrane potential and the extracellular potassium concentration indicated that the resting membrane potential is mainly determined by the membrane potassium conductance. Our data suggest the following mechanism of action for ouabain: (a) ouabain blocks Na+/K+ pump thereby increasing the intracellular sodium concentration; (b) increase in intracellular sodium inhibits membrane potassium conductance, which depolarizes the membrane and prolongs the slow wave plateau, resulting in an increase of the force of contraction. The direct contribution of the sodium pump to the resting membrane potential, if any, can only be minor (< 6 mV)." @default.
• W1990230662 created "2016-06-24" @default.
• W1990230662 creator A5078446730 @default.
• W1990230662 creator A5084249605 @default.
• W1990230662 date "1992-10-01" @default.
• W1990230662 modified "2023-10-18" @default.
• W1990230662 title "Ouabain-induced excitation of colonic smooth muscle due to block of K+ conductance by intracellular Na+ ions" @default.
• W1990230662 cites W1581232786 @default.
• W1990230662 cites W1880791719 @default.
• W1990230662 cites W1974424266 @default.
• W1990230662 cites W1975777248 @default.
• W1990230662 cites W1982455660 @default.
• W1990230662 cites W1991143420 @default.
• W1990230662 cites W1992280358 @default.
• W1990230662 cites W1994088839 @default.
• W1990230662 cites W2000740789 @default.
• W1990230662 cites W2003552383 @default.
• W1990230662 cites W2007605604 @default.
• W1990230662 cites W2011920501 @default.
• W1990230662 cites W2012448539 @default.
• W1990230662 cites W2022765359 @default.
• W1990230662 cites W2025941034 @default.
• W1990230662 cites W2034383472 @default.
• W1990230662 cites W2034895566 @default.
• W1990230662 cites W2056081019 @default.
• W1990230662 cites W2064289099 @default.
• W1990230662 cites W2070716170 @default.
• W1990230662 cites W2072805369 @default.
• W1990230662 cites W2077682224 @default.
• W1990230662 cites W2081349761 @default.
• W1990230662 cites W2081880339 @default.
• W1990230662 cites W2084754754 @default.
• W1990230662 cites W2091257254 @default.
• W1990230662 cites W2096041543 @default.
• W1990230662 cites W2119350257 @default.
• W1990230662 cites W2145830981 @default.
• W1990230662 cites W2157069171 @default.
• W1990230662 cites W2192656338 @default.
• W1990230662 cites W2268223071 @default.
• W1990230662 cites W2302568859 @default.
• W1990230662 cites W2414848855 @default.
• W1990230662 cites W2465187776 @default.
• W1990230662 cites W311374755 @default.
• W1990230662 doi "https://doi.org/10.1016/0014-2999(92)90771-u" @default.
• W1990230662 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1333977" @default.
• W1990230662 hasPublicationYear "1992" @default.
• W1990230662 type Work @default.
• W1990230662 sameAs 1990230662 @default.
• W1990230662 citedByCount "5" @default.
• W1990230662 crossrefType "journal-article" @default.
• W1990230662 hasAuthorship W1990230662A5078446730 @default.
• W1990230662 hasAuthorship W1990230662A5084249605 @default.
• W1990230662 hasConcept C114614502 @default.
• W1990230662 hasConcept C121932024 @default.
• W1990230662 hasConcept C12554922 @default.
• W1990230662 hasConcept C131453863 @default.
• W1990230662 hasConcept C134018914 @default.
• W1990230662 hasConcept C158494493 @default.
• W1990230662 hasConcept C163415756 @default.
• W1990230662 hasConcept C178790620 @default.
• W1990230662 hasConcept C181911157 @default.
• W1990230662 hasConcept C185592680 @default.
• W1990230662 hasConcept C2779133857 @default.
• W1990230662 hasConcept C2781295685 @default.
• W1990230662 hasConcept C28406088 @default.
• W1990230662 hasConcept C33923547 @default.
• W1990230662 hasConcept C39133596 @default.
• W1990230662 hasConcept C4141045 @default.
• W1990230662 hasConcept C517785266 @default.
• W1990230662 hasConcept C537181965 @default.
• W1990230662 hasConcept C55493867 @default.
• W1990230662 hasConcept C66974803 @default.
• W1990230662 hasConcept C71240020 @default.
• W1990230662 hasConcept C79879829 @default.
• W1990230662 hasConcept C86803240 @default.
• W1990230662 hasConceptScore W1990230662C114614502 @default.
• W1990230662 hasConceptScore W1990230662C121932024 @default.
• W1990230662 hasConceptScore W1990230662C12554922 @default.
• W1990230662 hasConceptScore W1990230662C131453863 @default.
• W1990230662 hasConceptScore W1990230662C134018914 @default.
• W1990230662 hasConceptScore W1990230662C158494493 @default.
• W1990230662 hasConceptScore W1990230662C163415756 @default.
• W1990230662 hasConceptScore W1990230662C178790620 @default.
• W1990230662 hasConceptScore W1990230662C181911157 @default.
• W1990230662 hasConceptScore W1990230662C185592680 @default.
• W1990230662 hasConceptScore W1990230662C2779133857 @default.
• W1990230662 hasConceptScore W1990230662C2781295685 @default.
• W1990230662 hasConceptScore W1990230662C28406088 @default.
• W1990230662 hasConceptScore W1990230662C33923547 @default.
• W1990230662 hasConceptScore W1990230662C39133596 @default.
• W1990230662 hasConceptScore W1990230662C4141045 @default.
• W1990230662 hasConceptScore W1990230662C517785266 @default.
• W1990230662 hasConceptScore W1990230662C537181965 @default.
• W1990230662 hasConceptScore W1990230662C55493867 @default.
• W1990230662 hasConceptScore W1990230662C66974803 @default.
• W1990230662 hasConceptScore W1990230662C71240020 @default.
• W1990230662 hasConceptScore W1990230662C79879829 @default.
• W1990230662 hasConceptScore W1990230662C86803240 @default.

• next