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• W1990236573 endingPage "725" @default.
• W1990236573 startingPage "712" @default.
• W1990236573 abstract "Models predictive of intestinal drug absorption are important in drug development to identify compounds with promising biopharmaceutical properties. Since permeability is a factor affecting absorption, cell culture models (e.g., Caco-2, MDCK) have been developed to predict drug transport from the intestinal lumen into the bloodstream. The differences as to how the assays are performed, along with heterogeneity of the cell lines, have lead to different permeability values for the same drug. Transport and metabolic properties of cultured cells can vary due to culture conditions, seeding density, passage number, confluency, filter support, monolayer age, and stage of differentiation. During the transport experiment, cell absorption properties can change due to the composition and pH of the transport buffer, solute concentration and solubility, temperature, additives and/or cosolvents, agitation, sampling schedule, sink conditions, and analytical methods. Such variability within a laboratory can be avoided by characterizing a cell culture method and setting acceptance criteria in terms of monolayer integrity, passive transport, and active transport. The repeated evaluation of reference compounds will then facilitate intra-laboratory comparisons." @default.
• W1990236573 created "2016-06-24" @default.
• W1990236573 creator A5067664883 @default.
• W1990236573 date "2008-02-01" @default.
• W1990236573 modified "2023-10-16" @default.
• W1990236573 title "Variability in Caco-2 and MDCK Cell-Based Intestinal Permeability Assays" @default.
• W1990236573 cites W1252895163 @default.
• W1990236573 cites W127055339 @default.
• W1990236573 cites W1512493536 @default.
• W1990236573 cites W1516634954 @default.
• W1990236573 cites W1521545709 @default.
• W1990236573 cites W1542020176 @default.
• W1990236573 cites W1566211379 @default.
• W1990236573 cites W1596283370 @default.
• W1990236573 cites W1596837460 @default.
• W1990236573 cites W1599886286 @default.
• W1990236573 cites W1599993198 @default.
• W1990236573 cites W1628890212 @default.
• W1990236573 cites W1755208670 @default.
• W1990236573 cites W1759961012 @default.
• W1990236573 cites W1904678284 @default.
• W1990236573 cites W1919773996 @default.
• W1990236573 cites W1963799213 @default.
• W1990236573 cites W1971832290 @default.
• W1990236573 cites W1972213949 @default.
• W1990236573 cites W1973005280 @default.
• W1990236573 cites W1974173736 @default.
• W1990236573 cites W1974742895 @default.
• W1990236573 cites W1976622833 @default.
• W1990236573 cites W1979196526 @default.
• W1990236573 cites W1983111851 @default.
• W1990236573 cites W1986421418 @default.
• W1990236573 cites W1986914646 @default.
• W1990236573 cites W1988958523 @default.
• W1990236573 cites W1995403069 @default.
• W1990236573 cites W2002463984 @default.
• W1990236573 cites W2002762671 @default.
• W1990236573 cites W2002807520 @default.
• W1990236573 cites W2003571134 @default.
• W1990236573 cites W2011768090 @default.
• W1990236573 cites W2013983226 @default.
• W1990236573 cites W2014813466 @default.
• W1990236573 cites W2015201186 @default.
• W1990236573 cites W2019214599 @default.
• W1990236573 cites W2019374792 @default.
• W1990236573 cites W2025033304 @default.
• W1990236573 cites W2028273867 @default.
• W1990236573 cites W2028358602 @default.
• W1990236573 cites W2030247333 @default.
• W1990236573 cites W2037029956 @default.
• W1990236573 cites W2038606604 @default.
• W1990236573 cites W2039246704 @default.
• W1990236573 cites W2041454039 @default.
• W1990236573 cites W2042223267 @default.
• W1990236573 cites W2046827775 @default.
• W1990236573 cites W2048743608 @default.
• W1990236573 cites W2049067591 @default.
• W1990236573 cites W2053484522 @default.
• W1990236573 cites W2055645153 @default.
• W1990236573 cites W2057402632 @default.
• W1990236573 cites W2060191811 @default.
• W1990236573 cites W2065602354 @default.
• W1990236573 cites W2071242727 @default.
• W1990236573 cites W2073862596 @default.
• W1990236573 cites W2074454682 @default.
• W1990236573 cites W2076248379 @default.
• W1990236573 cites W2078768423 @default.
• W1990236573 cites W2079911811 @default.
• W1990236573 cites W2080155982 @default.
• W1990236573 cites W2080465574 @default.
• W1990236573 cites W2081762279 @default.
• W1990236573 cites W2083504073 @default.
• W1990236573 cites W2083715780 @default.
• W1990236573 cites W2084994075 @default.
• W1990236573 cites W2087596583 @default.
• W1990236573 cites W2090751188 @default.
• W1990236573 cites W2091714673 @default.
• W1990236573 cites W2092815169 @default.
• W1990236573 cites W2094220461 @default.
• W1990236573 cites W2095307832 @default.
• W1990236573 cites W2101697465 @default.
• W1990236573 cites W2106448082 @default.
• W1990236573 cites W2114254209 @default.
• W1990236573 cites W2126547775 @default.
• W1990236573 cites W2132452783 @default.
• W1990236573 cites W2137724705 @default.
• W1990236573 cites W2145309113 @default.
• W1990236573 cites W2169333823 @default.
• W1990236573 cites W2204214583 @default.
• W1990236573 cites W239328926 @default.
• W1990236573 cites W2404082640 @default.
• W1990236573 cites W294850324 @default.
• W1990236573 cites W322314461 @default.
• W1990236573 cites W350581293 @default.
• W1990236573 cites W4229948187 @default.
• W1990236573 doi "https://doi.org/10.1002/jps.21010" @default.
• W1990236573 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17542022" @default.
• W1990236573 hasPublicationYear "2008" @default.

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