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• W1990245488 abstract "Although psilocybin has been trained in the rat as a discriminative stimulus, little is known of the pharmacological receptors essential for stimulus control. In the present investigation rats were trained with psilocybin and tests were then conducted employing a series of other hallucinogens and presumed antagonists. An intermediate degree of antagonism of psilocybin was observed following treatment with the 5-HT(2A) receptor antagonist, M100907. In contrast, no significant antagonism was observed following treatment with the 5-HT(1A/7) receptor antagonist, WAY-100635, or the DA D(2) antagonist, remoxipride. Psilocybin generalized fully to DOM, LSD, psilocin, and, in the presence of WAY-100635, DMT while partial generalization was seen to 2C-T-7 and mescaline. LSD and MDMA partially generalized to psilocybin and these effects were completely blocked by M-100907; no generalization of PCP to psilocybin was seen. The present data suggest that psilocybin induces a compound stimulus in which activity at the 5-HT(2A) receptor plays a prominent but incomplete role. In addition, psilocybin differs from closely related hallucinogens such as 5-MeO-DMT in that agonism at 5-HT(1A) receptors appears to play no role in psilocybin-induced stimulus control." @default.
• W1990245488 created "2016-06-24" @default.
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• W1990245488 date "2007-10-01" @default.
• W1990245488 modified "2023-10-17" @default.
• W1990245488 title "Psilocybin-induced stimulus control in the rat" @default.
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• W1990245488 doi "https://doi.org/10.1016/j.pbb.2007.06.003" @default.
• W1990245488 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2000343" @default.
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