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- W1990246277 abstract "We studied the effects of endothelin on the conversion of angiotensin I to angiotensin II in pulmonary artery endothelial cells. Endothelin had a novel effect on angiotensin I conversion. When endothelin was added to pulmonary artery endothelial cells, the conversion of angiotensin I to angiotensin II was enhanced about two-fold. The maximum stimulation was achieved at 10−sm of endothelin. This stimulatory effect was suppressed by angiotensin converting enzyme inhibitors such an enalapril. When the calcium antagonist, nifedipine, was incubated with 10−sm of endothelin, the conversion of angiotensin I to angiotensin II stimulated with endothelin was slightly suppressed by nifedipine. Enalapril (10−6m) completely inhibited the conversion of angiotensin I to angiotensin II in the presence of endothelin. These results suggest that endothelin may play an important role in regulating vascular tone by modulating the conversion of angiotensin I to angiotensin II." @default.
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- W1990246277 date "1990-08-01" @default.
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- W1990246277 title "Endothelin stimulates angiotensin I to angiotensin II conversion in cultured pulmonary artery endothelial cells" @default.
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- W1990246277 doi "https://doi.org/10.1016/0022-2828(90)90115-i" @default.
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