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• W1990253392 abstract "This phase 1 trial aimed to determine the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) of S-1 with concomitant intensity modulated radiation therapy (IMRT) as an adjuvant treatment for locally advanced gastric cancer. We consecutively enrolled patients with pathologically proved node-positive gastroesophageal or gastric adenocarcinoma (any TN + M0) after complete resection with negative margins (R0) or microscopic resection (R1). IMRT was delivered of 45 Gy (1.8 Gy/fraction, 5 days/week) for R0 patients or 45 Gy with a boost dose of 10.8 Gy for R1 patients. S-1 was administered every weekday at a dosage (mg/m2/d) of 30 (level I, n = 6), 40 (level II, n = 3), 50 (level III, n = 6), 60 (level IV, n = 3), 70 (level V, n = 3), and 80 (level VI, n = 6). An experienced physicist designed the IMRT plans using a five-to-seven-field, coplanar, sliding window technique on a treatment planning system. Twenty-seven patients were consecutively recruited. Grade 1-3 nausea (23 patients, 85.2%), anorexia (23 patients, 85.2%), leukopenia (23 patients, 85.2%), fatigue (19 patients, 70.4%), and thrombocytopenia (14 patients, 51.9%) were the most common toxicities. Grade 3 nausea and anorexia occurred in one level-I patient. Grade 3 thrombocytopenia occurred in one level-III patient. Overall, the adverse events were very mild and no Grade 4 toxicity was observed. MTD was never reached. The mean volume of the PTV was 866.3 cm3. IMRT plans provided dramatic normal tissue sparing with the technical parameters as follows (the means ± standard deviations): for left kidney, the mean dose (MD) was 13.86 ± 1.84 Gy and V20 (volume receiving a dose of 20 Gy or more) 21.4 ± 11.6%; for right kidney, the MD was 12.41 ± 2.99 Gy and V20 15.9 ± 6.1%; for the liver, the MD was 18.40 ± 1.87 Gy, and V30 0.7 ± 3.5%; the maximal dose for the spinal cord was 36.2 ± 2.82 Gy; for the small bowel and the colon, V45 were 13.0 ± 13.3% and 5.9 ± 6.1%, respectively. S-1 with concurrent IMRT was safe and pretty tolerable for locally advanced gastric cancer patients as an adjuvant setting. The MTD of S-1 was 80 mg/m2/d administered every weekday. The DLTs were nausea, anorexia, and thrombocytopenia." @default.
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• W1990253392 date "2014-09-01" @default.
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• W1990253392 title "Phase 1 Study of Concurrent S-1 and Intensity Modulated Radiation Therapy as Adjuvant Treatment for Locally Advanced Gastric Cancer" @default.
• W1990253392 doi "https://doi.org/10.1016/j.ijrobp.2014.05.766" @default.
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