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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990258811> ?p ?o ?g. }

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• W1990258811 abstract "It is established that drugs targeting viral proteins are at risk of generating resistant strains. However, drugs targeting host factors can potentially avoid this problem. Herein we report structure-activity relationship studies leading to the discovery of a very potent lead compound 6-fluoro-2-(5-isopropyl-2-methyl-4-phenoxyphenyl)quinoline-4-carboxylic acid (C44) that inhibits human dihydroorotate dehydrogenase (DHODH) with an IC50 of 1 nM, and viral replication of VSV and WSN-Influenza with an EC50 of 2 nM and 41 nM. We also solved the X-ray structure of human DHODH bound to C44, providing structural insight into the potent inhibition of biaryl ether analogs of brequinar." @default.
• W1990258811 created "2016-06-24" @default.
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• W1990258811 date "2013-04-25" @default.
• W1990258811 modified "2023-10-13" @default.
• W1990258811 title "SAR-Based Optimization of a 4-Quinoline Carboxylic Acid Analogue with Potent Antiviral Activity" @default.
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• W1990258811 doi "https://doi.org/10.1021/ml300464h" @default.
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