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- W1990267923 abstract "The DNA damage response (DDR) is an evolutionarily conserved signaling cascade that senses and responds to double-strand DNA breaks by organizing downstream cellular events, ranging from appropriate DNA repair to cell cycle checkpoints. In higher organisms, the DDR prevents neoplastic transformation by directly protecting the information contained in the genome and by regulating cell fate decisions, like apoptosis and senescence, to ensure the removal of severely damaged cells. In addition to these well-studied cell-autonomous effects, emerging evidence now shows that the DDR signaling cascade can also function in a paracrine manner, thus influencing the biology of the surrounding cellular microenvironment. In this context, the DDR plays an emerging role in shaping the damaged tumor microenvironment through the regulation of tissue repair and local immune responses, thereby providing a promising avenue for novel therapeutic interventions. Additionally, while DDR-mediated extracellular signals can convey information to surrounding, undamaged cells, they can also feedback onto DNA-damaged cells to reinforce selected signaling pathways. Overall, these extracellular DDR signals can be subdivided into two time-specific waves: a rapid bystander effect occurring within a few hours of DNA damage; and a late, delayed, senescence-associated secretory phenotype (SASP) generally requiring multiple days to establish. Here, we highlight and discuss examples of rapid and late DDR–mediated extracellular alarm signals." @default.
- W1990267923 created "2016-06-24" @default.
- W1990267923 creator A5034484927 @default.
- W1990267923 creator A5036894393 @default.
- W1990267923 creator A5049046475 @default.
- W1990267923 creator A5081364749 @default.
- W1990267923 date "2015-03-12" @default.
- W1990267923 modified "2023-10-14" @default.
- W1990267923 title "DDR-mediated crosstalk between DNA-damaged cells and their microenvironment" @default.
- W1990267923 cites W1963704214 @default.
- W1990267923 cites W1969464492 @default.
- W1990267923 cites W1970891016 @default.
- W1990267923 cites W1970924670 @default.
- W1990267923 cites W1970965314 @default.
- W1990267923 cites W1977362098 @default.
- W1990267923 cites W1981797176 @default.
- W1990267923 cites W1984185924 @default.
- W1990267923 cites W1985549756 @default.
- W1990267923 cites W1985775217 @default.
- W1990267923 cites W1989479849 @default.
- W1990267923 cites W1991293467 @default.
- W1990267923 cites W1995948727 @default.
- W1990267923 cites W1997484507 @default.
- W1990267923 cites W2001720505 @default.
- W1990267923 cites W2001733842 @default.
- W1990267923 cites W2001893028 @default.
- W1990267923 cites W2004273407 @default.
- W1990267923 cites W2004325862 @default.
- W1990267923 cites W2009105537 @default.
- W1990267923 cites W2010417927 @default.
- W1990267923 cites W2019276374 @default.
- W1990267923 cites W2027630134 @default.
- W1990267923 cites W2028169108 @default.
- W1990267923 cites W2028427311 @default.
- W1990267923 cites W2030075101 @default.
- W1990267923 cites W2030362606 @default.
- W1990267923 cites W2030795773 @default.
- W1990267923 cites W2033562377 @default.
- W1990267923 cites W2038078790 @default.
- W1990267923 cites W2039862710 @default.
- W1990267923 cites W2042140414 @default.
- W1990267923 cites W2042418128 @default.
- W1990267923 cites W2042499074 @default.
- W1990267923 cites W2044341880 @default.
- W1990267923 cites W2058647415 @default.
- W1990267923 cites W2061039816 @default.
- W1990267923 cites W2061765285 @default.
- W1990267923 cites W2065374619 @default.
- W1990267923 cites W2069519394 @default.
- W1990267923 cites W2074177924 @default.
- W1990267923 cites W2075497030 @default.
- W1990267923 cites W2077450385 @default.
- W1990267923 cites W2082231023 @default.
- W1990267923 cites W2084733813 @default.
- W1990267923 cites W2084969545 @default.
- W1990267923 cites W2090998580 @default.
- W1990267923 cites W2096846805 @default.
- W1990267923 cites W2108887402 @default.
- W1990267923 cites W2109445568 @default.
- W1990267923 cites W2115852450 @default.
- W1990267923 cites W2116054786 @default.
- W1990267923 cites W2125035574 @default.
- W1990267923 cites W2126525177 @default.
- W1990267923 cites W2131078803 @default.
- W1990267923 cites W2131974830 @default.
- W1990267923 cites W2135829603 @default.
- W1990267923 cites W2138297556 @default.
- W1990267923 cites W2139214771 @default.
- W1990267923 cites W2140930678 @default.
- W1990267923 cites W2141814583 @default.
- W1990267923 cites W2144318283 @default.
- W1990267923 cites W2145200068 @default.
- W1990267923 cites W2145846248 @default.
- W1990267923 cites W2146338506 @default.
- W1990267923 cites W2147030667 @default.
- W1990267923 cites W2148434747 @default.
- W1990267923 cites W2150940840 @default.
- W1990267923 cites W2151020715 @default.
- W1990267923 cites W2154903097 @default.
- W1990267923 cites W2155600913 @default.
- W1990267923 cites W2162942873 @default.
- W1990267923 cites W2165259537 @default.
- W1990267923 cites W2167894711 @default.
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- W1990267923 doi "https://doi.org/10.3389/fgene.2015.00094" @default.
- W1990267923 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4357297" @default.
- W1990267923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25815006" @default.
- W1990267923 hasPublicationYear "2015" @default.
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