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- W1990276332 endingPage "28" @default.
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- W1990276332 abstract "In Brief Objective To review the current data on the prognostic and therapeutic implications of tumor angiogenesis in gastrointestinal cancers. Summary Background Data Numerous studies have evaluated the prognostic value of tumor angiogenesis and the potential role of antiangiogenic therapy in various gastrointestinal cancers. Methods A Medline literature search was conducted using “angiogenesis” or the names of various angiogenic factors in combination with the names of gastrointestinal cancers as the key words. Results Several studies have demonstrated a significant prognostic impact of tumor microvessel density and tumor expression of angiogenic factors, in particular vascular endothelial growth factor (VEGF), in various gastrointestinal cancers. A few studies have suggested that circulating VEGF might be a useful prognostic marker. However, results were not consistent across all studies and were limited by the retrospective nature of most studies. Antiangiogenic therapy has been shown to be effective against all common gastrointestinal cancers in preclinical studies, but currently there are few clinical data with regard to antiangiogenic therapy in gastrointestinal cancers. Conclusions There is mounting evidence to suggest that assessment of tumor angiogenesis might provide a novel approach of prognostication in patients with gastrointestinal cancers. However, current results from retrospective studies need to be validated by prospective studies. Antiangiogenic therapy is a promising strategy of cancer treatment that might be particularly useful in combination therapy for unresectable cancers or as an adjuvant therapy for resectable tumors. Considerable experimental and clinical data have indicated a pivotal role of angiogenesis in tumor progression and metastasis. A substantial number of studies have examined the clinical significance of tumor angiogenesis in various gastrointestinal cancers, and antiangiogenic therapy in gastrointestinal cancers is now being evaluated in clinical trials. This article provides the gastrointestinal surgeons and oncologists with a comprehensive review of the prognostic and therapeutic implications of tumor angiogenesis in gastrointestinal cancers." @default.
- W1990276332 created "2016-06-24" @default.
- W1990276332 creator A5015257936 @default.
- W1990276332 creator A5041031736 @default.
- W1990276332 creator A5063344656 @default.
- W1990276332 date "2003-07-01" @default.
- W1990276332 modified "2023-10-17" @default.
- W1990276332 title "Clinical Significance of Angiogenesis in Gastrointestinal Cancers" @default.
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