Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990283560> ?p ?o ?g. }
- W1990283560 endingPage "191" @default.
- W1990283560 startingPage "184" @default.
- W1990283560 abstract "Protein synthesis and secretion by the choroid plexus (CP) has been implicated as a major source of certain proteins in cerebrospinal fluid (CSF), such as transthyretin. The suggestion that proteins are elaborated from CP through apocrine secretion has been borne out by the presence of newly labeled proteins in apical protrusions from CP (Agnew et al.: Cell and Tissue Research 208:261-281, 1980a). When the protrusions (aposomes) separate from the cells, they continue to incorporate labeled amino acids (Gudeman et al.: Tissue and Cell 19:101-109, 1987). In the present work the formation of aposomes in live CP explants indicated that these spheroids were not the result of fixation. Aposomes were also identified within rat CSF by immunohistochemistry with monoclonal directed against aposomes as well as with anti-transthyretin serum. The protein product of aposomes was characterized by 2-dimensional SDS-PAGE and compared to the protein products of whole CP tissue. Paradoxically, transthyretin, a heavily labeled protein in the tissue, was virtually undetected in the aposome synthetic profile. However, four other proteins were expressed in relatively equivalent amounts by the aposomes. The presence of mRNA in aposomes was detected with a poly dT probe, and the presence of actin was revealed by phalloidin staining of aposomes. These studies provide a more comprehensive definition of aposomes, but the functions of their secreted proteins remains to be determined." @default.
- W1990283560 created "2016-06-24" @default.
- W1990283560 creator A5046109279 @default.
- W1990283560 creator A5062047518 @default.
- W1990283560 creator A5064757340 @default.
- W1990283560 creator A5067747491 @default.
- W1990283560 date "1989-10-01" @default.
- W1990283560 modified "2023-10-01" @default.
- W1990283560 title "Release from live choroid plexus of apical fragments and electrophoretic characterization of their synthetic products" @default.
- W1990283560 cites W1510707687 @default.
- W1990283560 cites W1532754033 @default.
- W1990283560 cites W1598177992 @default.
- W1990283560 cites W1967021321 @default.
- W1990283560 cites W1967790293 @default.
- W1990283560 cites W1985274228 @default.
- W1990283560 cites W2014321075 @default.
- W1990283560 cites W2017233221 @default.
- W1990283560 cites W2021391478 @default.
- W1990283560 cites W2021538016 @default.
- W1990283560 cites W2024025372 @default.
- W1990283560 cites W2024312881 @default.
- W1990283560 cites W2036832507 @default.
- W1990283560 cites W2039499458 @default.
- W1990283560 cites W2042975557 @default.
- W1990283560 cites W2043722146 @default.
- W1990283560 cites W2049431994 @default.
- W1990283560 cites W2058268487 @default.
- W1990283560 cites W2082038537 @default.
- W1990283560 cites W2092959415 @default.
- W1990283560 cites W2147989356 @default.
- W1990283560 cites W2413447874 @default.
- W1990283560 cites W2883983821 @default.
- W1990283560 doi "https://doi.org/10.1002/jnr.490240209" @default.
- W1990283560 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2585546" @default.
- W1990283560 hasPublicationYear "1989" @default.
- W1990283560 type Work @default.
- W1990283560 sameAs 1990283560 @default.
- W1990283560 citedByCount "23" @default.
- W1990283560 countsByYear W19902835602012 @default.
- W1990283560 countsByYear W19902835602013 @default.
- W1990283560 countsByYear W19902835602015 @default.
- W1990283560 countsByYear W19902835602016 @default.
- W1990283560 countsByYear W19902835602018 @default.
- W1990283560 countsByYear W19902835602019 @default.
- W1990283560 countsByYear W19902835602020 @default.
- W1990283560 countsByYear W19902835602021 @default.
- W1990283560 countsByYear W19902835602023 @default.
- W1990283560 crossrefType "journal-article" @default.
- W1990283560 hasAuthorship W1990283560A5046109279 @default.
- W1990283560 hasAuthorship W1990283560A5062047518 @default.
- W1990283560 hasAuthorship W1990283560A5064757340 @default.
- W1990283560 hasAuthorship W1990283560A5067747491 @default.
- W1990283560 hasConcept C121157162 @default.
- W1990283560 hasConcept C134018914 @default.
- W1990283560 hasConcept C142669718 @default.
- W1990283560 hasConcept C1491633281 @default.
- W1990283560 hasConcept C153911025 @default.
- W1990283560 hasConcept C169760540 @default.
- W1990283560 hasConcept C185592680 @default.
- W1990283560 hasConcept C2776538271 @default.
- W1990283560 hasConcept C2776861759 @default.
- W1990283560 hasConcept C49039625 @default.
- W1990283560 hasConcept C529278444 @default.
- W1990283560 hasConcept C54355233 @default.
- W1990283560 hasConcept C55493867 @default.
- W1990283560 hasConcept C74864618 @default.
- W1990283560 hasConcept C86803240 @default.
- W1990283560 hasConcept C95444343 @default.
- W1990283560 hasConceptScore W1990283560C121157162 @default.
- W1990283560 hasConceptScore W1990283560C134018914 @default.
- W1990283560 hasConceptScore W1990283560C142669718 @default.
- W1990283560 hasConceptScore W1990283560C1491633281 @default.
- W1990283560 hasConceptScore W1990283560C153911025 @default.
- W1990283560 hasConceptScore W1990283560C169760540 @default.
- W1990283560 hasConceptScore W1990283560C185592680 @default.
- W1990283560 hasConceptScore W1990283560C2776538271 @default.
- W1990283560 hasConceptScore W1990283560C2776861759 @default.
- W1990283560 hasConceptScore W1990283560C49039625 @default.
- W1990283560 hasConceptScore W1990283560C529278444 @default.
- W1990283560 hasConceptScore W1990283560C54355233 @default.
- W1990283560 hasConceptScore W1990283560C55493867 @default.
- W1990283560 hasConceptScore W1990283560C74864618 @default.
- W1990283560 hasConceptScore W1990283560C86803240 @default.
- W1990283560 hasConceptScore W1990283560C95444343 @default.
- W1990283560 hasIssue "2" @default.
- W1990283560 hasLocation W19902835601 @default.
- W1990283560 hasLocation W19902835602 @default.
- W1990283560 hasOpenAccess W1990283560 @default.
- W1990283560 hasPrimaryLocation W19902835601 @default.
- W1990283560 hasRelatedWork W1975692580 @default.
- W1990283560 hasRelatedWork W1990283560 @default.
- W1990283560 hasRelatedWork W2042975557 @default.
- W1990283560 hasRelatedWork W2078440070 @default.
- W1990283560 hasRelatedWork W2078873833 @default.
- W1990283560 hasRelatedWork W2096964291 @default.
- W1990283560 hasRelatedWork W2153166537 @default.
- W1990283560 hasRelatedWork W2300509685 @default.
- W1990283560 hasRelatedWork W2411546001 @default.