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- W1990285880 abstract "Chronic depolarization greatly increases the survival of many types of neurons in culture. In at least some cases this enhancement of survival consists of the suppression of programmed cell death, a type of death occurring in developing neurons deprived of sufficient neurotrophic factor support. Available evidence suggests that the effect of depolarization on survival is mediated by a sustained rise of cytoplasmic free Ca2+, apparently caused by influx of Ca2+ through voltage-gated channels. This review discusses what is known about the mechanism by which prolonged depolarization and increased intracellular Ca2+ promote survival." @default.
- W1990285880 created "2016-06-24" @default.
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- W1990285880 date "1992-12-01" @default.
- W1990285880 modified "2023-09-23" @default.
- W1990285880 title "Suppression of programmed neuronal death by sustained elevation of cytoplasmic calcium" @default.
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- W1990285880 doi "https://doi.org/10.1016/0166-2236(92)90103-f" @default.
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