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• W1990286994 abstract "L'inhibine est une hormone glycoprotéique d'origine gonadique qui diminue de façon sélective la sécrétion antéhypophysaire d'hormone folliculo-stimulante (FSH). L'inhibine peut être mesurée soit in vivo par des techniques indirectes qui mettent en évidence une baisse des taux de FSH chez le rat castré, soit in vitro en évaluant la sécrétion de FSH par les cellules antéhypophysaires en culture. Plus récemment, des techniques radio-immunologiques ont été élaborées. Elles sont fondées sur des anticorps dirigés soit contre l'inhibine bovine, soit contre des peptides synthétiques mimant la portion amino-terminale de la sous-unité α de l'inhibine. Cependant, l'évaluation de l'intérêt clinique de l'inhibine est freinée par l'absence d'un dosage sensible, totalement spécifique et de réalisation rapide. Inhibin is a glycoprotein hormone of gonadal origin which specifically inhibits secretion of follicle-stimulating hormone (FSH) by the anterior pituitary gland. Inhibin was first detected by indirect assays based on either in vivo bioassay measuring a decrease in FSH production in castrated rats, or in vitro bioassay using cultured pituitary cells. However, evaluation of the potential clinical interest of inhibin and related molecules such as activin and follistatin in various physiological processes is still impaired by the absence of a sensitive, specific and rapid immunoassay." @default.
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• W1990286994 date "1991-06-01" @default.
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• W1990286994 title "Inhibine et molécules apparentées. Structures, activités biologiques et méthodes de dosage" @default.
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• W1990286994 doi "https://doi.org/10.1016/s0923-2532(05)80442-9" @default.
• W1990286994 hasPublicationYear "1991" @default.
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