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• W1990293522 startingPage "145" @default.
• W1990293522 abstract "In Brief Objective: Menopausal hot flashes may affect vascular function and perhaps explain conflicting data on cardiovascular disease (CVD) between observational and randomized hormone therapy (HT) studies. We prospectively assessed hot flash status in recently postmenopausal women and related it to a number of biochemical vascular surrogate markers for CVD. Methods: Healthy, nonsmoking women (n = 150) exhibiting a broad range (no, mild, moderate, severe) of hot flashes and an onset of menopause within the previous 0.5 to 3 years were studied with laboratory tests for lipids, lipoproteins, apolipoproteins, high-sensitivity C-reactive protein, and sex hormone-binding globulin. Results: Apart from marked differences in hot flashes, the groups showed comparable levels of estrone, estradiol, or free estradiol index. The levels of total cholesterol (3.7-9.1 mmol/L) were similar between the groups (P = 0.744), and hypercholesterolemia (>6.5 mmol/L) was encountered equally often (P = 0.699). No difference was seen in high-, low-, or very low-density lipoproteins, triglycerides, apolipoprotein A-1, apolipoprotein B (or their ratio), or lipoprotein(a) between the groups. The levels of sex hormone-binding globulin and high-sensitivity C-reactive protein correlated negatively with each other (r = −0.204; P = 0.013) but showed no dependence on hot flashes (P = 0.531 and P = 0.215, respectively). Conclusions: No baseline difference in lipid or nonlipid CVD risk factors was observed between women with hot flashes (potential HT users) and women with no or mild hot flashes (potential HT nonusers). This may imply that hot flash status per se cannot explain the difference between observational and randomized trials. Prospectively recorded hot flashes of different severities were not related to lipids, lipoproteins, apolipoproteins, sex hormone-binding globulin, or high-sensitivity C-reactive protein in recently postmenopausal women. This may imply that hot flash status per se cannot explain the conflict between observational studies and randomized hormone therapy trials." @default.
• W1990293522 created "2016-06-24" @default.
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• W1990293522 date "2010-01-01" @default.
• W1990293522 modified "2023-09-27" @default.
• W1990293522 title "Biochemical markers for cardiovascular disease in recently postmenopausal women with or without hot flashes" @default.
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• W1990293522 doi "https://doi.org/10.1097/gme.0b013e3181acefd5" @default.
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