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- W1990301097 abstract "The abilities of 4 antimalaria drugs (Daraprim, Fansidar, Nivaquine and Camoquine) on their own and in combination with aflatoxin B 1 to induce prophage in tester strains E. coli D 21 and D 22 were studied. The 4 drugs were found to induce prophage in the tester strains; Daraprim and Fansidar without the need for activation by liver mixed function oxidases (S9 microsomal fraction), while Nivaquine and Camoquine did require activation by this system. Aflatoxin B 1 was used as a positive control in all the tests. The combined effects of each of the drugs with aflatoxin B 1 were lower than that of the individual drugs acting alone. From these results, it may be concluded that the drugs may, on their own, pose a carcinogenic hazard to the population in the Nigerian environment exposed to them. In addition, the depression of prophage induction observed when the drugs were combined with aflatoxin B 1 may be indicative of a common target site of action in the tester strains." @default.
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- W1990301097 date "1989-04-01" @default.
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- W1990301097 title "Prophage induction by 4 antimalaria drugs (Daraprim, Fansidar, Nivaquine and Camoquine) and in combination with aflatoxin B1" @default.
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- W1990301097 doi "https://doi.org/10.1016/0165-1218(89)90105-5" @default.
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