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- W1990303463 abstract "To obtain information on the effects of a divalent cation (Ca2+) on the membrane properties of the lipid A analog, E5531, the particle size, ξ potential, membrane fluidity and pharmacokinetices was investigated in rats after the addition of calcium ion. Within a molar ratio for [Ca2+]/[E5531] ≤ 3, the presence of Ca2+ increased the potentials of the E5531 membrane, but had no effect on particle size. Ca2+ decreased membrane fluidity and the pharmacokinetics in rats. These effects of Ca2+ on the membrane properties of E5531 particles could be eliminated by the addition of EDTA." @default.
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- W1990303463 date "2005-01-01" @default.
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- W1990303463 title "Investigation on the relationship between the physicochemical properties of particles composed of a novel lipid A analog, E5531, and its pharmacokinetics" @default.
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- W1990303463 doi "https://doi.org/10.1163/1568552054194177" @default.
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