Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990305004> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W1990305004 abstract "Single oral dose toxicities of six hexamethylmelamine samples with different particle size distributions were evaluated in Osborne-Mendel rats. The calculated LD50 values for the 6 samples were 1706 to 2150 mg/kg )10,236 to 12,900 mg/m2). The two samples with median particle size less than 40 micron were more toxic than the other 4 samples. Among the latter samples, severity of toxic effects was not correlated with particle size. Leukocytes, lymphocytes, platelets and body weight showed dose-related decreases for all samples. Particle size appeared to have a minimal effect on these variables. The drug produced toxic effects on rapidly proliferating tissues: lymphoid, hematopoietic and germinal epithelium. At lethal doses, microscopic lesions were lymphoid tissue hypoplasia, bone marrow hypoplasia with elevated myeloid:erythroid ratios and spermatogenic arrest. The major target organs at nonlethal doses were bone marrow and germ cells, with germinal epithelium showing the most severe lesions." @default.
- W1990305004 created "2016-06-24" @default.
- W1990305004 creator A5008331171 @default.
- W1990305004 creator A5028163989 @default.
- W1990305004 creator A5052386526 @default.
- W1990305004 creator A5069267843 @default.
- W1990305004 date "1979-01-01" @default.
- W1990305004 modified "2023-09-25" @default.
- W1990305004 title "Effect of Particle Size Distribution on Hexamethylmelamine Toxicity in Rats" @default.
- W1990305004 cites W2038633896 @default.
- W1990305004 doi "https://doi.org/10.3109/01480547908998248" @default.
- W1990305004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/121072" @default.
- W1990305004 hasPublicationYear "1979" @default.
- W1990305004 type Work @default.
- W1990305004 sameAs 1990305004 @default.
- W1990305004 citedByCount "0" @default.
- W1990305004 crossrefType "journal-article" @default.
- W1990305004 hasAuthorship W1990305004A5008331171 @default.
- W1990305004 hasAuthorship W1990305004A5028163989 @default.
- W1990305004 hasAuthorship W1990305004A5052386526 @default.
- W1990305004 hasAuthorship W1990305004A5069267843 @default.
- W1990305004 hasConcept C105702510 @default.
- W1990305004 hasConcept C109159458 @default.
- W1990305004 hasConcept C123765429 @default.
- W1990305004 hasConcept C126322002 @default.
- W1990305004 hasConcept C134018914 @default.
- W1990305004 hasConcept C142724271 @default.
- W1990305004 hasConcept C16685009 @default.
- W1990305004 hasConcept C185592680 @default.
- W1990305004 hasConcept C2778466210 @default.
- W1990305004 hasConcept C2780007613 @default.
- W1990305004 hasConcept C2780327212 @default.
- W1990305004 hasConcept C28328180 @default.
- W1990305004 hasConcept C29730261 @default.
- W1990305004 hasConcept C71924100 @default.
- W1990305004 hasConcept C86803240 @default.
- W1990305004 hasConcept C95444343 @default.
- W1990305004 hasConceptScore W1990305004C105702510 @default.
- W1990305004 hasConceptScore W1990305004C109159458 @default.
- W1990305004 hasConceptScore W1990305004C123765429 @default.
- W1990305004 hasConceptScore W1990305004C126322002 @default.
- W1990305004 hasConceptScore W1990305004C134018914 @default.
- W1990305004 hasConceptScore W1990305004C142724271 @default.
- W1990305004 hasConceptScore W1990305004C16685009 @default.
- W1990305004 hasConceptScore W1990305004C185592680 @default.
- W1990305004 hasConceptScore W1990305004C2778466210 @default.
- W1990305004 hasConceptScore W1990305004C2780007613 @default.
- W1990305004 hasConceptScore W1990305004C2780327212 @default.
- W1990305004 hasConceptScore W1990305004C28328180 @default.
- W1990305004 hasConceptScore W1990305004C29730261 @default.
- W1990305004 hasConceptScore W1990305004C71924100 @default.
- W1990305004 hasConceptScore W1990305004C86803240 @default.
- W1990305004 hasConceptScore W1990305004C95444343 @default.
- W1990305004 hasLocation W19903050041 @default.
- W1990305004 hasLocation W19903050042 @default.
- W1990305004 hasOpenAccess W1990305004 @default.
- W1990305004 hasPrimaryLocation W19903050041 @default.
- W1990305004 hasRelatedWork W105724951 @default.
- W1990305004 hasRelatedWork W1891647864 @default.
- W1990305004 hasRelatedWork W1967018160 @default.
- W1990305004 hasRelatedWork W2027577106 @default.
- W1990305004 hasRelatedWork W2395603459 @default.
- W1990305004 hasRelatedWork W2417028238 @default.
- W1990305004 hasRelatedWork W2440084133 @default.
- W1990305004 hasRelatedWork W2499553427 @default.
- W1990305004 hasRelatedWork W2737200409 @default.
- W1990305004 hasRelatedWork W2158079764 @default.
- W1990305004 isParatext "false" @default.
- W1990305004 isRetracted "false" @default.
- W1990305004 magId "1990305004" @default.
- W1990305004 workType "article" @default.