Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990306543> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W1990306543 endingPage "157" @default.
- W1990306543 startingPage "148" @default.
- W1990306543 abstract "Chronic idiopathic urticaria (CIU) manifests as frequently occurring, short-lived wheals, surrounded by a bright-red flare, and often accompanied by angioedema. The cause of CIU is undefined and its diagnosis requires exclusion of other conditions with somewhat similar symptoms. Recent evidence has indicated that IgG autoantibodies directed against high-affinity IgE receptors (FcepsilonRI) may be involved in the pathophysiology of CIU. Following the release of mast cell or basophil-derived histamine, this mediator binds to H(1) and H(2) receptors, leading to vasodilatation and increased vascular permeability. Individuals with CIU may be unable to conduct normal daily activities; therefore, prompt initiation of effective treatment is essential. General management of patients should include avoidance of substances likely to trigger or intensify episodes. Treatment with antihistamines is the mainstay of pharmacotherapy for CIU. Selection of antihistamine therapy for patients with CIU should be based on the following key properties: (1) proven clinical efficacy in providing a high rate of symptom improvement, (2) rapid onset of action and a long-lasting response, and (3) an excellent safety profile and a high degree of tolerability. The benefit of some second-generation antihistamines is limited by sedation, drug-drug interactions, or a variable therapeutic response. The H(1)-receptor antagonist desloratadine is a new, once-daily treatment option that is potent and nonsedating, and has a low potential for drug-drug interactions. Desloratadine has a rapid onset of action and has been shown to effectively and safely reduce pruritus and the number and size of hives in patients with CIU, leading to improvements in quality of life." @default.
- W1990306543 created "2016-06-24" @default.
- W1990306543 creator A5060664616 @default.
- W1990306543 date "2003-05-01" @default.
- W1990306543 modified "2023-10-12" @default.
- W1990306543 title "Chronic idiopathic urticaria for the generalist" @default.
- W1990306543 cites W1980421164 @default.
- W1990306543 cites W1991790975 @default.
- W1990306543 cites W1997887280 @default.
- W1990306543 cites W1998908263 @default.
- W1990306543 cites W2005514362 @default.
- W1990306543 cites W2005587919 @default.
- W1990306543 cites W2011597517 @default.
- W1990306543 cites W2014448032 @default.
- W1990306543 cites W2015782988 @default.
- W1990306543 cites W2022204280 @default.
- W1990306543 cites W2027588628 @default.
- W1990306543 cites W2040737274 @default.
- W1990306543 cites W2070319865 @default.
- W1990306543 cites W2083666610 @default.
- W1990306543 cites W2088576983 @default.
- W1990306543 cites W2105955333 @default.
- W1990306543 cites W2116150353 @default.
- W1990306543 cites W2125871165 @default.
- W1990306543 cites W2163282502 @default.
- W1990306543 cites W2335582143 @default.
- W1990306543 cites W4210949141 @default.
- W1990306543 cites W4245107297 @default.
- W1990306543 cites W4245755353 @default.
- W1990306543 cites W4246780690 @default.
- W1990306543 cites W4254034209 @default.
- W1990306543 cites W47817786 @default.
- W1990306543 doi "https://doi.org/10.1016/s0953-6205(03)00035-9" @default.
- W1990306543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12798212" @default.
- W1990306543 hasPublicationYear "2003" @default.
- W1990306543 type Work @default.
- W1990306543 sameAs 1990306543 @default.
- W1990306543 citedByCount "8" @default.
- W1990306543 countsByYear W19903065432012 @default.
- W1990306543 countsByYear W19903065432015 @default.
- W1990306543 countsByYear W19903065432017 @default.
- W1990306543 crossrefType "journal-article" @default.
- W1990306543 hasAuthorship W1990306543A5060664616 @default.
- W1990306543 hasConcept C1122143 @default.
- W1990306543 hasConcept C126322002 @default.
- W1990306543 hasConcept C16005928 @default.
- W1990306543 hasConcept C197934379 @default.
- W1990306543 hasConcept C2776129107 @default.
- W1990306543 hasConcept C2776880894 @default.
- W1990306543 hasConcept C2777995640 @default.
- W1990306543 hasConcept C2778375690 @default.
- W1990306543 hasConcept C2780035454 @default.
- W1990306543 hasConcept C2780113039 @default.
- W1990306543 hasConcept C2781025919 @default.
- W1990306543 hasConcept C2909530563 @default.
- W1990306543 hasConcept C46821324 @default.
- W1990306543 hasConcept C500440147 @default.
- W1990306543 hasConcept C71924100 @default.
- W1990306543 hasConcept C98274493 @default.
- W1990306543 hasConceptScore W1990306543C1122143 @default.
- W1990306543 hasConceptScore W1990306543C126322002 @default.
- W1990306543 hasConceptScore W1990306543C16005928 @default.
- W1990306543 hasConceptScore W1990306543C197934379 @default.
- W1990306543 hasConceptScore W1990306543C2776129107 @default.
- W1990306543 hasConceptScore W1990306543C2776880894 @default.
- W1990306543 hasConceptScore W1990306543C2777995640 @default.
- W1990306543 hasConceptScore W1990306543C2778375690 @default.
- W1990306543 hasConceptScore W1990306543C2780035454 @default.
- W1990306543 hasConceptScore W1990306543C2780113039 @default.
- W1990306543 hasConceptScore W1990306543C2781025919 @default.
- W1990306543 hasConceptScore W1990306543C2909530563 @default.
- W1990306543 hasConceptScore W1990306543C46821324 @default.
- W1990306543 hasConceptScore W1990306543C500440147 @default.
- W1990306543 hasConceptScore W1990306543C71924100 @default.
- W1990306543 hasConceptScore W1990306543C98274493 @default.
- W1990306543 hasIssue "3" @default.
- W1990306543 hasLocation W19903065431 @default.
- W1990306543 hasLocation W19903065432 @default.
- W1990306543 hasOpenAccess W1990306543 @default.
- W1990306543 hasPrimaryLocation W19903065431 @default.
- W1990306543 hasRelatedWork W141509808 @default.
- W1990306543 hasRelatedWork W1990306543 @default.
- W1990306543 hasRelatedWork W1996958492 @default.
- W1990306543 hasRelatedWork W2016523948 @default.
- W1990306543 hasRelatedWork W2027778258 @default.
- W1990306543 hasRelatedWork W2060522854 @default.
- W1990306543 hasRelatedWork W2088942574 @default.
- W1990306543 hasRelatedWork W2150163190 @default.
- W1990306543 hasRelatedWork W2157370005 @default.
- W1990306543 hasRelatedWork W2319396915 @default.
- W1990306543 hasVolume "14" @default.
- W1990306543 isParatext "false" @default.
- W1990306543 isRetracted "false" @default.
- W1990306543 magId "1990306543" @default.
- W1990306543 workType "article" @default.